Pengaruh Konsumsi Jambu Biji terhadap Peningkatan Jumlah Trombosit Pasien Demam Berdarah Dengue
Abstract
Dengue hemorrhagic fever or DHF is an infectious disease caused by the dengue virus and characterized by thrombocytopenia. Thrombocytopenia that persists in DHF can cause life-threatening complications. Monitoring the platelet count, in addition to the hematocrit level, is important to determine the severity of DHF. Therapy for DHF currently focuses on supportive and symptomatic therapy. Alternative therapy using guava (Psidium guajava L.) is believed to help the healing process of DHF by increasing the number of platelets. This study aims to determine the effect of consuming guava on increasing the number of platelets in DHF patients. The method used is to search literature according to the topic through the Google Scholar database with the keywords (jambu biji) OR (Psidium guajava) AND trombosit OR thrombocyte AND (demam berdarah dengue) OR (dengue hemorrhagic fever) in the period 2017-2022. Some literature states that the consumption of guava has a significant effect on increasing the number of platelets in DHF patients. Guava contains the flavonoid compounds quercetin and vitamin C which play a role in the production of platelets and inhibits the replication of the dengue virus.
References
W. H. Wang et al., “Dengue hemorrhagic fever
–
A systemic literature review of current
perspectives on pathogenesis, prevention and
control,” J. Microbiol. Immunol. Infect., pp. 1
–
16,
2020.
[2]
Kemenkes RI, Profil Kesehatan Indonesia 2021.
Jakarta, 2022.
[3]
A. H. Nurarif and H. Kusuma, Aplikasi Asuhan
Keperawatan Berdasarkan Diagnosa Medis dan
NANDA NIC
-
NOC. Yogyakarta: Mediaction
Publishing, 2015.
[4]
K. H. Sellahewa, “Pathogenesis of
Dengue
Haemorrhagic Fever and Its Impact on
CaseManagement,” ISRN Infect. Dis. rather, pp.
1
–
6, 2013.
[5]
WHO, Comprehensive guidelines for prevention
and control of dengue and dengue haemorrhagic
fever, no. 1. 2011.
[6]
Menteri
Kesehatan
Republik
Indones
ia,
Keputusan
Menteri
Kesehatan
Republik
Indonesia. Indonesia, 2021.
[7]
A. Wilder
-
Smith, E. E. Ooi, O. Horstick, and B.
Wills, “Dengue,” Lancet, vol. 393, no. 10169, pp.
350
–
363, 2019.
[8]
A. Suseno and Nasronudin, “Pathogenesis of
Hemorrhagic Due To Deng
ue Virus,” Indones. J.
Trop. Infect. Dis., vol. 5, no. 4, p. 107, 2015.
[9]
R. Hamood, M. Tirosh, N. Fallach, G. Chodick,
E. Eisenberg, and O. Lubovsky, “Prevalence and
incidence of osteoarthritis: A population‐based
retrospective cohort study,” J. Clin. M
ed., vol.
10, no. 4282, pp. 1
–
11, 2021.
[10]
N. A. Sugianto, “Pathophysiology of Dengue
Haemorrhagic Fever,” World J. Pharm. Sci., vol.
10, no. 14, pp. 218
–
223, 2021.
[11]
P. G. Daswani, M. S. Gholkar, and T. J. Birdi,
“Psidium guajava: A Single Plant for
Multiple
Health Problems of Rural Indian Population,”
Pharmacogn. Rev., vol. 11, pp. 167
–
174, 2017.
[12]
A. I. Trujillo
-
Correa, D. C. Quintero
-
Gil, F. Diaz
-
Castillo, W. Quiñones, S. M. Robledo, and M.
Martinez
-
Gutierrez, “In vitro and in silico anti
-
dengue
activity of compounds obtained from
Psidium guajava through bioprospecting,” BMC
Complement. Altern. Med., vol. 19, no. 1, pp. 1
–
16, 2019.
[13]
N. Atik, S. Tarawifa, E. Avriyanti, A. R.
Rahmadi, and D. Hilmanto, “Psidium Guajava L.
Extract Increases Plate
let Count Through
Enhancement of Stem Cell Factor Expression in
Thrombocytopenic Mice Model,” Int. J. Pharm.
Pharm. Sci., vol. 10, no. 1, p. 23, 2018.
[14]
G. Berlian, O. M. Tandrasasmita, and R. R.
Tjandrawinata, “Trombinol, a bioactive fraction
of Psidiu
m guajava, stimulates thrombopoietin
expression in HepG2 cells,” Asian Pac. J. Trop.
Biomed., vol. 7, no. 5, pp. 437
–
442, 2017.
[15]
C. T. P. Hosea, A. W. Jamaluddin, and Y. M.
Adikurniawan, “Uji Aktivitas Jus Buah Jambu
Biji Berdaging Merah (Psidium Guaja
va L.)
terhadap Peningkatan Trombosit pada Mencit
(Mus
Musculus
L.)
yang
Diinduksi
Kloramfenikol,” J. Ilm. As
-
Syifaa, vol. 10, no. 2,
pp. 170
–
178, 2018.
[16]
Marisa and E. Suriani, “Gambaran Hasil
Pemeriksaan Trombosit Darah pada Penderita
DBD sesudah Meng
konsumsi Jambu Biji
(Psidium guajava) di RST Solok Tahun 2018,”
Sainstek J. Sains dan Teknol., vol. 11, no. 2, pp.
78
–
82, 2019.
[17]
R. Widhawati and M. Solehah, “Pengaruh Jambu
Biji terhadap Kenaikan Trombosit Pasien
Demam Berdarah Dengue (DBD) di Ruang
A
yana Rumah Sakit Permata Ibu Kunciran
Tangerang,” J. Kesehat., vol. 6, no. 2, pp. 1
–
10,
2018.
[18]
A. J. Az
-
Zahra and M. N. Al Jihad, “Peningkatan
Kadar Trombosit pada Pasien Anak Demam
Berdarah Dengue (DBD) dengan Mengonsumsi
Jus Jambu Biji Merah,” Ners M
uda, vol. 3, no. 2,
2022.
[19]
D. C. Rahayuningrum and H. D. Morika,
“Pengaruh Kosumsi Jus Jambu Biji Merah
terhadap Peningkatan Kadar Trombosit pada
Nutriology: Jurnal Pangan, Gizi, Kesehatan, Vol. 04, No. 01, April 2023
6
Pasien Demam Berdarah Dengue (DBD),” J.
Kesehat. Saintika Meditory, vol. 2, no. 1, pp. 79
–
88, 2019.
[20]
I. W. P. Sutirta
-
Yasa
, G. A. E. T. Putra, and A.
Rahmawati, “Trombositopenia pada Demam
Berdarah Dengue,” Medicina (B. Aires)., vol. 43,
no. 2, pp. 114
–
121, 2012.
[21]
E. L. De Azeredo, R. Q. Monteiro, and L. M. De
-
Oliveira Pinto, “Thrombocytopenia in dengue:
Interrelationship
between
virus and
the
imbalance between coagulation and fibrinolysis
and inflammatory mediators,” Mediators
Inflamm., 2015.
[22]
Y. L. Boo, S. Y. Lim, H. S. P’ng, C. C. K. Liam,
and N. C. Huan, “Persistent thrombocytopenia
following dengue fever: What
should we do?,”
Malaysian Fam. Physician, vol. 14, no. 3, pp. 71
–
73, 2019
This work is licensed under a Creative Commons Attribution 4.0 International License.