Analysis of Prophylactic Antibiotic Use in Caesarean Section Patiens

  • Anggi Monica Universitas Bumigora
  • Muh. Wisda Praja Ramdhany Universitas Bumigora
  • Made Sandhi Pratama Putra Universitas Bumigora
Keywords: Caesarean section, Prophylactic antibiotics, Usage analysis

Abstract

Cesarean section (C-section) is a delivery method involving surgical incisions on the abdomen and uterus. C-section carries the risk of postoperative complications such as surgical site infection (SSI). Hence, there is a need for prophylactic antibiotic administration. Prophylactic antibiotics are used to prevent infection complications resulting from surgery and are administered before, during, and after the operation. The selection of antibiotics is crucial because inappropriate antibiotic use can lead to resistance. This research aims to analyze the usage profile and evaluate the rationality of prophylactic antibiotics in C-section procedures at Wira Bhakti Hospital. This study is a non-experimental descriptive research in which retrospective data collection was conducted in the form of medical records of C-section patients. Also, the rationality assessment was performed using the Gyssens method. The research findings show that the most used antibiotics are ceftriaxone (70.6%), cefotaxime (25%), and cefoperazone (4.4%). Meanwhile, the rationality assessment using Gyssens' method shows that all prophylactic antibiotic use falls under the categories of IVA (more effective alternative) and IVD (narrower spectrum alternative).

References

Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, Fish DN, Napolitano LM, Sawyer RG, Slain D, Steinberg JP, Weinstein RAratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, Fish DN, Napolitano LM, Sawyer RG, Slain D, St, W. R. (2013). Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. Am J Health Syst Pharm, 70(3), 95–283. https://doi.org/10.2146/ajhp120568
Cahyana, I. P. P., Puspitasari, C. E., & Hasina, R. (2021). Pola Penggunaan Antibiotik Profilaksis pada Pasien Section Caesarea di RSUD Provinsi NTB Tahun 2018. Archives Pharmacia, 3(1), 9–15.
Chairani, F., Puspitasari, I., & Asdie, R. H. (2023). Insidensi dan Faktor Risiko Infeksi Luka Operasi pada Bedah Obstetri dan Ginekologi di Rumah Sakit. Journal of Management and Pharmacy Practice, 9(4), 274. https://doi.org/10.22146/jmpf.48024
Fajriyah, S., Farida, U., Agustina, S., Winduhani Astuti, L., & Ambar Widyaningrum, E. (2023). The Use of Prophylactic Antibiotics for Cesarean Section Delivery and The Incident of Surgical Site Infection. Indonesian Journal of Pharmaceutical Education, 3(2), 247–255. https://doi.org/10.37311/ijpe.v3i2.19864
Hardiyanti, R. (2020). Definisi SC Menurut Oxorn. Jurnal Stikes Siti Hajar, 2(1), 96–105. https://media.neliti.com/media/publications/423022-none-54bd4d36.pdf
Harwiyanti, N. T., Nugraha, D. P., & Amalia, A. (2022). Analisis Efektivitas Cefazoline dan Ceftriaxone sebagai Antibiotik Profilaksis Bedah Sesar di RSIA Trisna Medika Tulungagung Periode Oktober–Desember 2021. Jurnal Sains Dan Kesehatan, 4(5), 500–510. https://doi.org/10.25026/jsk.v4i5.1272
Karminingtyas, S. R., Oktianti, D., & Furdiyanti, N. H. (2018). Keefektifan Penggunaan Antibiotik Profilaksis pada Pasien Bedah Sesar (Sectio Caesarea). Cendekia Journal of Pharmacy, 2(1), 22–31. https://doi.org/10.31596/cjp.v2i1.14
Kemenkes RI. (2018). Riset Kesehatan Dasar.
Kemenkes RI. (2021). Peraturan Menteri Kesehatan Tentang Pedoman Umum Penggunaan Antibiotik.
McEvoy. (2005). AHFS : Drug Information. American Society of Health System Pharmacists, USA.
Megawati, S., Rahmawati, F., & Wahyono, D. (2015). Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Bedah. Jurnal Manajemen Dan Pelayanan Farmasi, 5(2), 127–134.
Mutmainah, N., Setyati, P., & Handasari, N. (2014). Evaluation of the Use and Effectiveness of Antibiotics for Prophylactic in Patients with Cesarean Section at Hospitals in Surakarta in 2010. Indonesian Journal of Clinical Pharmacy, 3(2), 44–49. https://doi.org/10.15416/ijcp.2014.3.2.44
Novietaningtyas, Kurniasih, F. (2018). Evaluasi Penggunaan Obat Antiobiotik Profilaksis pada Pasien Oprasi Sesar (Sectio Caesarea) di RSUD Kabupaten Tanggerang Tahun 2018. VII(2), 68–74.
Nurhidayah, N., Sunarti, & Kusuma, I. Y. (2021). Evaluasi Penggunaan Antibiotik Profilaksis Pada Pasien Bedah Sesar (Sectio Caesarea) Di RSUD Prof. Dr. Margono Soekarjo Tahun 2020. Seminar Nasional Penelitian Dan Pengabdian Kepada Masyarakat (SNPPKM), 390–396. https://prosiding.uhb.ac.id/index.php/SNPPKM/article/download/860/76
Purwaningsih, A. E. D. A., Chandra, S. W., & Harsono, S. B. (2023). Kajian Penggunaan Antibiotik Profilaksis Pada Pasien Bedah Cesar Di Rsud Ibu Fatmawati Soekarno Kota Surakarta Tahun 2020. Journal Pharmacopoeia, 2(1), 54–64. https://doi.org/10.33088/jp.v2i1.352
Thaharah, R., Fadraersada, J., & Amir, M. M. (2015). Penggunaan Antibiotik Profilaksis Pada Pasien Bedah Sesar (Cesarean section) Di RSUD A.W.S Samarinda. 1–12.
Ulfa, N. M., Fandinata, S. S., & Hendrawati, Y. (2019). Analisis Efektifitas Cefazoline, Ceftriaxone, Cefotaxime Sebagai Antibiotik Profilaksis Pada Pasien Sectio Caesarea. Jurnal Ilmiah As-Syifaa, 11(2), 103–111. https://doi.org/10.33096/jifa.v11i2.567
Vessal, G., Namazi, S., Davarpanah, M. A., & Foroughinia, F. (2011). Evaluation of prophylactic antibiotic administration at the surgical ward of a major referral hospital, Islamic republic of Iran. Eastern Mediterranean Health Journal, 17(8), 663–667. https://doi.org/10.26719/2011.17.8.663
Wardoyo EH, Tjoa E, Ocvyanty D, M. L. (2014). Infeksi luka operasi (ILO) di bangsal kebidanan dan kandungan RSUP cipto mangunkusumo (RSCM). Laporan Serial Kasus Bulan Agustus-Oktober 2011., CDK-216. 4(5), 332–335.
WHO. (2021). Antimicrobal Resistance Multi-Partner Trust Fund annual report 2021.
Wibowo, M., Dwi Utamiasih, T., & Ratna Juwita, D. (2019). Evaluasi Penggunaan Antibiotik Profilaksis pada Operasi Sesar di Rumah Sakit Swasta Purwokerto Evaluation of Prophylactic Antibiotic Use for Cesarean Section In a Purwokerto Private Hospital. Pharmaceutical Journal of Indonesia, 16(02), 372–385.
Published
2024-04-30