Biocity Journal of Pharmacy Bioscience and Clinical Community
situs togel slot zeus slot depo pulsa 5k slot Biocity Journal is one of scientific journal in Bumigora University, under. Lembaga. Penelitian dan Pengabadian kepada Masyarakat (LPPM) managerial and arrangement. Biocity journal intended to contribute by allocate publication for lecturers, researchers and practitioners in internal and external academics of Bumigora University. Biocity Journal is a collection of publication journals, including all aspects of Pharmacy Bioscience, Pharmaceutical sciences, Technology of Herbal Formulations, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Health and Environmental issues and Pharmacy Clinical Community. Biocity Journal terbit 2 (dua) kali dalam 1 tahun pada periode Genap (Oktober) dan Ganjil (April). Cakupan dan Fokus Publikasi Biocity Journal adalah Ilmu Farmasi Bahan Alam, Sains klinis, klinis komunitas dan luasan dari keilmuan farmasi terkait . Untuk informasi lebih lanjut, hubungi admin via email biocity.journal@universitasbumigora.ac.id
Department of Pharmacy, Bumigora University
Validity and Reliability Test of the Indonesian Version of the SF-36 Questionnaire to Measure the Quality of Life of Hemodialysis Patients with Chronic Kidney Failure
Chronic kidney disease (CKD) not only impacts physiological aspects but also reduces the patient's quality of life. Assessment of the quality of life is important as an indicator of the success of therapy and disease management. This study aims to determine the validity and reliability of the Indonesian version of the Short Form-36 questionnaire in measuring the quality of life of CKD patients undergoing hemodialysis. This study used a descriptive cross-sectional design with a prospective approach. Data were collected by completing the Short Form-36 questionnaire by CKD patients undergoing outpatient care at RSUD Mataram. Validity analysis was performed using Pearson correlation, while reliability was tested with Cronbach's alpha. The number of respondents was 30 patients. The results showed that the Short Form-36 questionnaire had a Pearson correlation value > 0.40 and a Cronbach's alpha value > 0.70, indicating that this instrument is valid and reliable. Thus, the Indonesian version of the Short Form-36 questionnaire can be used to assess the quality of life of CKD patients.
Chronic kidney disease, quality of life, reliability, SF-36 questionnaire, validity.
Copyright (c) 2025 Baiq Indriswari, Fitri Apriliany, Novitarini http://creativecommons.org/licenses/by-sa/4.0
Analysis of the Decision to Use Herbal Medicine and Conventional Medicine Among Productive Age Groups in Pangkah District
Herbal medicine and conventional medicine are two primary treatment options commonly used by the productive age population in addressing health issues. This study aims to determine the percentage of medicine preference, the dominant factors influencing decision-making, as well as the knowledge of medicinal plants and attitudes of the productive age community toward the use of herbal and conventional medicines. The research employed a mixed-methods using questionnaires and interviews through stratified random sampling. The results showed that 61% of respondents preferred conventional medicine, while 39% chose herbal medicine. The dominant factor influencing the use of herbal medicine was its minimal side effects, whereas the main reason for choosing conventional medicine was its effectiveness in treating diseases. Descriptive analysis concluded that the productive age population tends to prefer conventional medicine over herbal medicine for daily treatment.
Copyright (c) 2025 Dhea Ayu Khoirunnisa, Osie Listina, Ery Nourika Alfiraza http://creativecommons.org/licenses/by-sa/4.0
Analgesic Test on the Combination of Papaya Leaves (Carica papaya L.) and Moringa Leaves (Moringa oleifera L.) Extract on White Mice (Mus Musculus) Using Writhing Test
Ethnomedicinal plants that have been proven as analgesics are moringa leaves (Moringa oleifera L.) and papaya leaves (Carica papaya L.). The purpose of this study is to determine the analgesic activity of a combination of papaya and moringa leaf extracts. Analgesic testing used the writhing method. A total of 25 mice were grouped into 5 treatment groups, namely negative control (CMC Na 1%), positive control (mefenamic acid 500mg/70kgBW), group I (moringa leaf extract 400mg/kgBW), group II (papaya leaf extract 600mg/kgBW), and group III (combination of moringa leaf extract 200mg/kgBW and papaya leaf extract 300mg/kgBW). The results of the study were obtained using the formula for calculating the percentage of analgesic power and tested using the Post Hoc test and the Least Significant Difference (LSD) test. Based on the analysis, a significant difference was obtained between the treatment group and the negative control. The highest percentage of analgesic effect was obtained from group III, the combination of moringa leaf extract and papaya leaf extract at 56.4%. This result is equivalent to the positive control, with the administration of mefenamic acid.
Analgesic, Mefenamic acid, Moringa leaves, Papaya leaves, Writhing test
Copyright (c) 2025 Arifina Fahamsya, Endang Instriningsih, Ananda Kukuh Adi Karang http://creativecommons.org/licenses/by-sa/4.0
Qualitative Test of Cyanide Compound Content in Plants using Picrate Method
Indonesian people have traditionally utilized various local plants as alternative food sources. These plants are widely available and have considerable nutritional value; however, some of them are known to contain toxic compounds such as cyanide (HCN), which can be harmful to human health if not properly processed. Therefore, this study aimed to examine the presence of cyanide compounds in several of these commonly consumed plants. The research was conducted using a qualitative test based on the picrate method. The samples tested included cassava, cassava leaves, bamboo shoots, gadung tubers, and taro tubers. The findings indicated that all tested samples showed positive results for the presence of cyanide, as evidenced by the observed color change from yellow to reddish-brown. In conclusion, all five types of plant samples tested contained cyanide, emphasizing the importance of proper processing techniques to reduce toxicity levels before consumption by the public.
Cyanide; Picrate paper; Plant; Qualitative
Copyright (c) 2025 Ayudia Cipta Khairani, Mia Ariasti, Lalu Busyairi Muhsin, Lalu Sanik Wahyu Fadil Amrulloh, Ruprika Dwi Martayuni http://creativecommons.org/licenses/by-sa/4.0
Profile of Diarrhea Medication Use Across Age Groups at the Military Academy Medical Center in Magelang during 2021
The prevalence of diarrhea is widespread in developing countries and is a leading cause of global morbidity and mortality. This article presents a profile of medication use in the management of diarrhea based on age groups. The study utilized a quantitative approach by analyzing 123 prescriptions from diarrhea patients at the Military Academy Health Clinic in Magelang during 2021. Data were analyzed using frequency distribution tabulations with Microsoft Excel 2016. The results indicate that antidiarrheal prescriptions are age-adjusted, probiotics are the primary choice for infants and children, while loperamide is recommended for adolescents to the elderly. Adsorbents serve as an alternative across all age groups. Management of older patients also considers prognosis and accompanying symptoms, which includes antibiotics, antiulcer medications, and antispasmodics. Supportive therapies such as zinc supplementation and oral rehydration are applied across all age categories.
Adsorben, antidiare, probiotik, terapi suportif
Copyright (c) 2025 Diwang Ningsih Endang Sakti, Setiyo Budi Santoso, Puspita Septie Dianita http://creativecommons.org/licenses/by-sa/4.0
Antibacterial Activity Test of Bougainvillea glabra Leaf Ethanol Extract on Staphylococcus aureus Bacteria
Bougainvillea leaves contain various secondary metabolite compounds, such as flavonoids, tannins, and saponins. These compounds have the potential to be antibacterial to treat infectious diseases caused by the pathogenic bacteria Staphylococcus aureus. This study aims to determine the antibacterial activity of bougainvillea leaf ethanol extract against the growth of S. aureus bacteria. This study carried out antibacterial activity tests using the agar well-diffusion method. Data analysis used the One-way ANOVA statistical test, with the Shapiro-Wilk normality test and the Levene homogeneity test. The results of phytochemical tests showed that the ethanol extract of bougainvillea leaves contains flavonoids, tannins, and saponins. In antibacterial tests with concentrations of 25%, 50%, 75%, and 100%, the diameter of the inhibition zone obtained ranged from 20-27.3 cm. This inhibition zone is included in the strong to very strong category. In addition, statistical tests showed that each concentration of bougainvillea leaf ethanol extract affected the growth of S. aureus bacteria compared to negative controls. Based on the description above, bougainvillea leaf ethanol extract has the potential to inhibit the growth of S. aureus.
Copyright (c) 2024 Mirna Legistari, Muhammad Eka Putra Ramandha, Baiq Yulia Hasni Pratiwi http://creativecommons.org/licenses/by-sa/4.0
Antibacterial Activity of Ethanol Extract of Marigold Flower (Tagetes erecta Linn.) against Staphylococcus aureus and Escherichia coli Bacteria
Gemitir flowers (Tagetes erecta Linn.) contain secondary metabolite compounds such as flavonoids, phenolics, saponins and carotenoids which have the potential as antibacterials that can be used in treating infections caused by pathogenic bacteria Staphylococcus aureus and Escherichia coli. The purpose of this study was to determine the effective concentration of etanol extract of gemitir flowers and the comparison of antibiotic inhibition with etanol extract of gemitir flowers in inhibiting the growth of S. aureus and E. coli bacteria. This study is an experimental study and was analyzed using the One Way ANOVA statistical test. The results showed that gemitir flower extract positively contained secondary metabolites in the form of flavonoids, phenolics and saponins. The antibacterial activity test of etanol extract of gemitir flowers can inhibit S. aureus and E. coli at concentrations of 85%, 90%, 95% and 100% with the diameter of the inhibition zone obtained of 17-31.6 mm which is included in the strong-very strong category. Based on the description above, it can be concluded that the etanol extract of gemitir flowers has the potential to inhibit the growth of S. aureus and E. coli bacteria.
Antibacterial activity, E. coli, S. aureus, Tagetes erecta Linn.
Copyright (c) 2024 unggu marsah http://creativecommons.org/licenses/by-sa/4.0
Factors that Influence Pregnant Women's Knowledge about Neonatal Asphyxia
Neonatal asphyxia is one of the causes of lack of blood flow or gas exchange to or from the fetus in the period immediately before, during, or after the birth process. According to data from the World Health Organization (WHO), 28 billion babies die after the first 28 days because that time is the adaptation period experienced by babies to determine whether they can survive or not. One of the leading causes is asphyxia, which results in 11% of infant deaths. This research aims to determine the factors that influence pregnant women's knowledge about neonatal asphyxia based on age, parity, and maternal education. This research is an analytical survey with a cross-sectional approach in the Kolakaasi Community Health Center work area. The research sample used was 75 respondents with a questionnaire instrument. The research results show that the statistical test results using the chi-square test, the probability is smaller α (p < α) (0.001 <0.05). This result statistically shows that there is a significant relationship between age, parity, and maternal education on knowledge about neonatal asphyxia. Therefore, it can be concluded that age, parity, and maternal education influence maternal knowledge regarding neonatal asphyxia.
Age, Education, Neonatal asphyxia, Parity, Pregnant women
Copyright (c) 2024 Hernah Riana, Nur Afni, Jumiyati Jumiyati http://creativecommons.org/licenses/by-sa/4.0
Factors Influencing Mothers' Knowledge about Seizures in Toddlers
Febrile seizures are the most common neurological disorder in children, with 1 in 25 children having one febrile seizure. Febrile convulsions are seizures that occur when the body temperature rises (rectal temperature over 38°C) due to an extracranial process. Febrile seizures can result in behavioral disturbances as well as decreased intelligence and academic achievement. According to the World Health Organization (WHO), it is estimated that the number of children who experience febrile seizures in the world is more than 21.65 million and more than 216 thousand children die. Therefore, it is important that mothers know about seizures. This study aims to determine the factors that influence maternal knowledge about seizures based on age, parity and maternal education. This research is an analytic survey with a cross sectional approach. This study was conducted in the working area of Puskesmas Kolaka. The research sample was 82 respondents where the instrument used was a questionnaire. The results of the study there is an influence between age and maternal knowledge about seizures p=0.015, parity with maternal knowledge about seizures p=0.003, education with maternal knowledge about seizures p=0.025. Conclusion. there is an influence between age, parity and maternal education about seizures. Suggestions to improve mothers' knowledge about seizures by providing education and promotion about handling toddlers who experience febrile seizures.
Copyright (c) 2024 Jumiyati, Hernah Riana, Nur Afni http://creativecommons.org/licenses/by-sa/4.0
Evaluation of the Level of Medication Adherence of Antiepileptic Drugs (AEDs) on Cognitive Function of Children
Epilepsy is a chronic brain disorder with various causes characterized by recurrent attacks. Epilepsy can affect all ages, including children, which affects around 40%-50%. Epilepsy can have an impact on memory disorders, either caused by symptoms of epilepsy itself, antiepileptic drugs (AEDs), psychosocial factors, or comorbidities. Patients with epilepsy are generally advised to consume AEDs for more than 3 months. This antiepileptic treatment takes a long time, so it is very susceptible to causing patient non-compliance in taking AEDs. Therefore, this study aims to determine the level of compliance of pediatric epilepsy patients and whether there is a relationship between compliance and the cognitive function of pediatric patients. In this study, 54 respondents were used from the Mataram City Hospital polyclinic. Compliance was measured using the Morisky Medication Adherence Scale 8 item (MMAS-8) questionnaire and cognitive function measure using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina). The result based on the MMAS-8 shows that 7.4% of respondents had high compliance, 61.1% had moderate compliance, and 31.5% had low compliance. Data analysis used the Chi-Square test with α = 0.01 and obtained a significance value (p-value = 0.329). Based on these results, it can be concluded that the level of compliance is moderate, and there is no relationship between compliance and cognitive function.
Anti-epileptic drugs, children, cognitive function, medication adherence
Copyright (c) 2024 Rizki Putri Ayu Dwi Anida, I Nyoman Bagus Aji Kresnapati, Baiq Yulia Hasni Pratiwi http://creativecommons.org/licenses/by-sa/4.0
The Influence of Reminding through WhatsApp on Medication Adherence in Pulmonary Tuberculosis Patients
Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. M. tuberculosis enters the body through inhaled air and spreads in the lungs. In 2021, Mataram City detected a total of 739 tuberculosis cases. Many tuberculosis patients still exhibit low adherence to taking their medication. This research investigates the influence of WhatsApp reminders on medication adherence in pulmonary tuberculosis patients. This is an analytical observational study with a quasi-experimental design that employs a prospective pre-test and post-test approach. The data for this study was collected from outpatient patients at RSUD Kota Mataram. The result indicates a significant improvement in medication adherence among pulmonary tuberculosis patients, with a significant value of the Wilcoxon test (p = 0.000, <0.05). The conclusion drawn from this study is that reminders through WhatsApp influence medication adherence in pulmonary tuberculosis patients at RSUD Kota Mataram.
Copyright (c) 2024 Yovi Agus Saputra, Fitry Apriliany, Muh. Wisda Praja Ramdhany http://creativecommons.org/licenses/by-sa/4.0
Phytochemical Profile and Antibacterial Activity of Sea Kekara Flower (Canavalia rosea) Using Disc Diffusion Method
Bacterial infection is one of the leading causes of chronic diseases and ongoing risks of mortality that continuously threaten public health globally. Improper use of antibiotics can lead to pathogenic bacteria developing resistance to antibiotics and cause dangerous side effects. Therefore, searching for alternative antibiotic sources derived from natural materials is essential. One type of plant that has the potential as an antibacterial agent is Canavalia rosea. This research aims to qualitatively assess the phytochemical content using tube methods and evaluate the antibacterial activity of the ethyl acetate fraction of Canavalia rosea extract using the disc diffusion method. Canavalia rosea leaves were extracted using a maceration method using 96% ethanol, and fractionation was done using ethyl acetate. Phytochemical analysis showed alkaloid, saponin, flavonoid, polyphenol, and tannin compounds in the Canavalia rosea flower extract. The antibacterial activity of the ethyl acetate fraction of the extract showed a significant inhibition zone against the growth of Staphylococcus aureus bacteria. At a concentration of 9 mg/mL, the inhibition zone reached 20.31 ± 0.27 mm, falling into the moderate to strong category. While at a concentration of 1.5 mg/mL, the inhibition zone reached 5.13 ± 0.32 mm, indicating lower inhibitory effects. Statistical analysis showed that the ethyl acetate fraction of Canavalia rosea extract has significant antibacterial activity, with each concentration having different effects in inhibiting the growth of S. aureus.
Copyright (c) 2024 Irman Idrus, Efa Kelya Nasrun, Muhammad Eka Putra Ramandha
The Relationship between Gastritis Incidence and History of Non-Steroidal Anti-Inflammatory Drug (NSAID) Use in Patients Undergoing Endoscopy
Gastritis is inflammation of the gastric mucosa, one of which is caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs). It is very common that NSAIDs are used to treat pain, fever, and inflammatory processes. This study aims to examine the relationship between the incidence of gastritis and a history of NSAIDs use. The research method use in this study is a retrospective cohort design of which the data is collected through interview of patients and their families. The patients medical records at the Mataram City Regional Hospital was also collected. Testing was carried out using the Pearson Correlation test. The result shows that gastritis patients were dominated by people aged 36-55 years (46.43%) and 49 of them were female (58.33%). The Pearson Correlation test shows no significant relationship between the incidence of gastritis and a history of NSAID use, with a p-value> 0.05 and an r-value < 1. This indicates a weak relationship between gastritis and the use of NSAIDs. Therefore, the history of NSAIDs use is insignificant as the main reason for gastritis. Gastritis can also be caused by other factors such as age, lifestyle, and stress levels.
Copyright (c) 2024 Kintan Nandini Nirmala Putri, Fitry Apriliany, Muh. Wisda Praja http://creativecommons.org/licenses/by-sa/4.0
Analysis of Prophylactic Antibiotic Use in Caesarean Section Patiens
Cesarean section (C-section) is a delivery method involving surgical incisions on the abdomen and uterus. C-section carries the risk of postoperative complications such as surgical site infection (SSI). Hence, there is a need for prophylactic antibiotic administration. Prophylactic antibiotics are used to prevent infection complications resulting from surgery and are administered before, during, and after the operation. The selection of antibiotics is crucial because inappropriate antibiotic use can lead to resistance. This research aims to analyze the usage profile and evaluate the rationality of prophylactic antibiotics in C-section procedures at Wira Bhakti Hospital. This study is a non-experimental descriptive research in which retrospective data collection was conducted in the form of medical records of C-section patients. Also, the rationality assessment was performed using the Gyssens method. The research findings show that the most used antibiotics are ceftriaxone (70.6%), cefotaxime (25%), and cefoperazone (4.4%). Meanwhile, the rationality assessment using Gyssens' method shows that all prophylactic antibiotic use falls under the categories of IVA (more effective alternative) and IVD (narrower spectrum alternative).
Copyright (c) 2024 Anggi Monica, Muh. Wisda Praja Ramdhany, Made Sandhi Pratama Putra http://creativecommons.org/licenses/by-sa/4.0
Relationship between Characteristics and the Level of Patient Family's Knowledge regarding Beyond Use Date (BUD) of Dry Syrup Medicines
Most households in Indonesia keep a stock of medicines, but the public's knowledge of medicine storage remains low. The term BUD in drug storage is very important to know because BUD is related to the stability and quality of drugs. If drug storage is not appropriate, it can result in irrational drug use. This research aims to determine the relationship between characteristics and the patient's family's level of knowledge about the BUD of dry syrup at the Mataram City Regional Hospital. This research is a type of analytical observational research with a cross-sectional design that uses a valid (0.411-0.780) and a reliable (>0.06) questionnaire instrument. The respondents involved in this study were 60 guardians of patients who received dry syrup medication. The level of knowledge of the patient's guardians regarding BUD for dry syrup is dominated by the excellent category. The highest results of filling out the questionnaire were 56 people, with a correct answer of 76% - 100%. The bivariate analysis using chi-square shows that the characteristic that is related to the level of knowledge about BUD dry syrup medicine is the level of education (p=0.007). The domain of information sources supporting BUD for dry syrup medicine also relates to the respondents' knowledge level of BUD for dry syrup (p=0.000). This study concludes that only the characteristics of the level of education have a relationship with the level of knowledge of the patient's guardians regarding BUD dry syrup.
Copyright (c) 2024 Nur Azizah Atmi, Muh. Wisda Praja Rhamdany, Made Sandi Pratama Putra http://creativecommons.org/licenses/by-sa/4.0
The Effect of Variations in HPMC and Carbopol Bases on The Physical Stability of Okra (Abelmoschus esculentus L.) Fruit Gel Formulations
Okra fruit (Abelmoschus esculentus L.) is a vegetable that is often used as medicine. Okra fruit contains flavonoids which are antioxidants. Gel formulation with a concentration of 5%, and various combinations of HPMC and carbopol bases. This research aims to determine the physical stability of gel preparations and the effect of variations in the concentration of gelling ingredients in the preparations. The gel formulation consists of 4 formulas, namely F0, F1, F2, and F3. Physical stability tests include organoleptic tests (odor, color and texture), homogeneity, pH, spreadability, stickiness, viscosity and synergy. Tests were carried out for 14 days of storage, namely on days 1, 3, 5, 7, and 14 at room temperature (25℃). The observation results showed that in the organoleptic test there was no change in color, odor and texture in the gel preparation during 14 days of storage. The four gel formulas are homogeneous and there is no synergy. Variations in the combination of HPMC and carbopol bases affect the physical properties of the gel, including pH, viscosity, spreadability and adhesion. HPMC and Carbopol affect the pH of the preparation, the higher the Carbopol content and the lower the HPMC content, the more acidic it is. Carbopol and HPMC affect the values of spreadability, viscosity and adhesion because the higher the concentration of carbopol and HPMC produces a thick gel preparation so that the spreadability decreases, viscosity increases and adhesion also increases.
Analysis of Physical and Chemical Tests of Bidara Leaves (Ziziphus spina-christi L.) Dried Using a Tray Dryer Machine with Different Temperatures
The Bidara plant (Ziziphus spina-christi L) is a kind of small evergreen tree. Bidara plants are easy to find in Indonesia, especially in Sumbawa Regency, West Nusa Tenggara. Bidara leaves have many pharmacological potentials, including antioxidants, antibacterial, antiparasitic and anti-cancer. Bidara leaves can be developed into efficacious herbal products. The drying process greatly affects the quality of bidara leaves. Temperature in the drying process is an important factor because it can affect the content of bioactive compounds in bidara leaves. The purpose of this study was to determine the effect of drying temperature on physical and chemical properties. The dryer used in this drying is a tray dryer. The experimental design used in this study was a completely randomized design (CRD) with one factor. The temperatures used were 45, 50 and 55°C with a drying time of 3 hours. The results showed that the drying temperature affected the physical and chemical properties of bidara leaves. The best treatment for drying bidara leaves is drying at 55°C for a weight loss of 90.8%; water content 33.8% and temperature 45℃ for protein content 14.23%; Flavonoid content 11.71%.
Copyright (c) 2023 Al Fira Safitri, Devi Tanggasari
Analysis of Adverse Drug Reactions (ADRs) Using Antibiotic for Community Acquired Penumonia (CAP) Disease of Toddler
Pneumonia is an infection that causes inflammation of the lung tissue so that the lung sacs are filled with infectious agents and are the main cause of infant mortality in the world. The initial therapy for pneumonia is the use of antibiotics. Irrational use of antibiotics can lead to ADRs. Adverse Drug Reactions (ADRs) often cause obstacles in the implementation of treatment. The purpose of this study was to see how ADRs influence the use of antibiotics on the clinical outcomes of pneumonia patients. The method analytic observational study using a cross-sectional design which is carried out prospectively, by collecting data on inpatients. Data were obtained from interviews with patients and/or patient families using the Naranjo questionnaire, as well as searches of patient medical records during the period January - March 2023. Analysis of ADRs on the use of antibiotics on outcomes was analyzed by the Likelihood ratio. This study was dominated by patients aged <2 years (61.5%) with improved outcomes (97.15%). The results obtained showed that there was no significant relationship between ADRs using antibiotics and patient outcomes with a p>0.05 (p=0.798). The conclusion of this study is that there is no effect of ADRs using antibiotics on patient outcomes.
Copyright (c) 2023 Fanny Dwi Febriyana, Fitry Apriliani, Muh Isnaini Zuhri
The Effect of Different Drying Temperatures Using a Tray Dryer on the Physical and Chemical Characteristics of Cayenne Pepper (Capsicum frutescens L.)
Cayenne pepper (Capsicum frutescens L.) is a potential vegetable crop that has high economic value and has the potential to continue to be developed, but cayenne pepper is a type of fruit that is easily damaged, therefore proper post-harvest handling is needed, one of which is drying. The purpose of this study was to determine the effect of different drying temperatures on physical analysis (weight loss) and chemical analysis (moisture content, vitamin C and capsaicin content). The dryer used in this study was a tray dryer. The experimental design used was a one-factor Completely Randomized Design (CRD) with 3 treatments. The temperatures used in this study were 40, 50, and 55°C. Based on the results of the study, it was found that the best decrease in weight loss in drying cayenne pepper was at 55°C with a decrease in weight loss of 62.67%. The best decrease in water content for drying cayenne pepper was at 55°C with a total moisture content of 50.3%. The best vitamin C content was found at 45°C, which was 0.65%, and the best capsaicin content for drying cayenne pepper was found at 45°C, which was 244.4702 ppm with an SHU level of 730.776.
Copyright (c) 2023 Susilawati Susilawati, Devi Tanggasari
Analysis of Side Effects of Corona Virus Disease-19 (COVID-19) Vaccine Booster Usage on Healthcare Workers
The Coronavirus Disease 2019 (COVID-19) is an infectious condition caused by the SARS-CoV-2 virus. This virus has undergone mutations, leading to new variants that have contributed to the increase in COVID-19 cases. Governments have initiated vaccination efforts as part of their strategies to curb the spread, particularly among healthcare workers. However, concerns have arisen regarding the occurrence of post-vaccination side effects. The objective of this study is to identify and categorize the side effects that arise after administering the COVID-19 (booster) vaccine, specifically the Moderna COVID-19 Vaccine®. The study employs a cross-sectional approach, collecting data through interviews and questionnaire completion among medical staff at Puskesmas Santong in April 2023. The study's findings reveal that out of 69 respondents, 94.2% experienced side effects following vaccination, while 5.8% did not encounter any. The majority of these side effects fall into the "probable" category (69.6%) according to the Naranjo Scale Algorithm. Common systemic side effects include fever (60.9%), dizziness (43.5%), fatigue (33.3%), muscle aches (31.9%), joint pain (13%), chills (11.6%), headache (10.1%), nausea (4.3%), runny nose (1.4%), and sneezing (1.4%). Local side effects, such as injection site pain, were reported by 34.8% of the respondents. The majority of these side effects persisted for 2 days (42%).
Copyright (c) 2023 Handini Mulianti, Muhammad Isnaini Zuhri, Widani Darma Isasih http://creativecommons.org/licenses/by-sa/4.0
Analisis Pengaruh Paparan Kebisingan, Suhu dan Kelembaban Udara terhadap Tekanan Darah Karyawan
Health and safety at work at PT Santosa Utama Lestari needs to be improved in order to provide a sense of comfort for workers, both directly and indirectly, in some parts or the possibility of having dangerous risk factors due to exposure, temperature and humidity, this is caused by industries that are active with the use of production machines in the corn drying industrial activities of PT. Santosa Utama Lestari Bima Unit. This study aims to analyze the effect of exposure to blood, temperature and humidity on the pressure of employees at PT. Santosa Utama Lestari Bima Unit. This research uses descriptive qualitative data analysis method. Based on the results of this study, the results of the effect of the intensity of the intensity, temperature and humidity at work on systolic blood pressure can be seen the coefficient of determination of the R Square value of 0.166 which implies that the influence of the independent variables (noise, temperature and air) simultaneously on the variables (blood pressure) systolic) was 16.6% percent. While the remaining 80.4% is influenced by factors outside the variables of this study. While the diastolic pressure can be seen the coefficient of determination R Square value of 0.246 which implies that the effect of the independent variables, temperature and humidity simultaneously on the variable (Dystolic pressure) is 0.61%, while the remaining 93.9% is influenced by other factors. outside of this research.
Kebisingan, Suhu, Kelembapan Udara, Tekanan Darah
Copyright (c) 2025 Dores Prandika, Haryandi Haryandi http://creativecommons.org/licenses/by-sa/4.0
Thalassemia is a genetic disorder in red blood cells so sufferers must do blood transfusions throughout their lives. Diagnosis is made based on anamnesis, physical examination, and supported by supporting examinations. Management in general is to do a blood transfusion. Management can be different for each individual depending on the condition of the patient. This literature review was made to increase knowledge about thalassemia through literature studies. Study searches were carried out through books and library websites such as PubMed and Google Scholar on related topics. The types of articles selected include review articles, narrative reviews, books, and research results which are publications in Indonesian or English as the main source.
Copyright (c) 2023 I Dewa Ayu Natih Canis Paloma http://creativecommons.org/licenses/by-sa/4.0
Physical and Chemical Quality Analysis of Traditional Sumbawa Face Mask (SemeBabak) from the Bark of Mango Golek Tree (Mangifera indica Linn)
The people in Sumbawa Regency, especially in Pungkit village, have been using traditional face mask products, namely the Seme Babak mask, which protects facial skin from the sun when doing activities all day outside the room. The traditional Seme Babak mask is made from the main ingredients, namely mango tree trunks and rice supporting ingredients, white glutinous rice and jackfruit seeds. The purpose of this study was to deterne the physical quality (spreadability, absorption, adhesion, particle size, homogeneity, moisture content) and to determine the chemical quality of the Seme Babak Typical Sumbawa masks with antioxidants and pH. This type of research is observational research and laboratory experiments. Based on the results of laboratory tests, the physical test results obtained an average particle size of 60 mesh or 0.25 mm, absorption power of 8 ml, adhesion of 6.43 seconds, spreadability of 5.1 cm, homogeneity, moisture content of 11% and chemical test results, the average value of the antioxidant test the IC50 value of the Seme Babak powder mask preparation is classified as a strong antioxidant at an IC50 value of more than 50 and less than 100, namely 68.2212 ppm and the pH level meets the requirements, namely the pH level because the pH value is in the range of 4.5-8.0.
Copyright (c) 2023 Devi Tanggasari, Rika Dwi Septianingsih http://creativecommons.org/licenses/by-sa/4.0
Decompression Sickness Type 1 in Traditional Fishermen: A Literature Review
Decompression sickness (DCS) is a collection of symptoms caused by the formation of air bubbles in the blood or tissues during or after a decrease in environmental pressure (decompression). In general, the main symptoms of DCS type 1 (pain-only beds) are muscle pain and weakness. So to diagnose Decompression Disease (DCS) type 1, it is based on the symptoms and the history of diving. Type 1 decompression sickness is managed by choosing initial treatment in the form of giving 100% oxygen through a face mask or, if needed, through intubation. While hyperbaric oxygen therapy can be used for definitive therapy if it is available in primary or secondary health care facilities.
Copyright (c) 2023 Ni Wayan Dewi, Kadek Diah P Sutanegara, Muhammad N Praramdana, Rizqi Al Kasiron, Decky Aditya Zulkarnaen http://creativecommons.org/licenses/by-sa/4.0
Ginger (Zingiberis officinale) Extraction and Thin Layer Chromatography (TLC) Separation Test
Ginger (Zingiberis Officinale) is a type of plant that belongs to the rhizome plant type, ginger is commonly used by the community as an ingredient for herbal drinks, based on this, it is necessary to have a simple extraction that can be used by the wider community to obtain a purer ginger extract, in this study it was conducted that the extraction or separation process of 100 grams of ginger simplicia through the maceration process yielded 27.9 grams, then a purity test was carried out using the principle of TLC (Thin Layer Chromatography) test with eluent or the mobile phase used was methanol, ethyl acetate and N hexane with a ratio of 7:7:6, and an Rf result of 0.18 was obtained based on the distance of the extraction spot divided by the distance traveled by the eluent, and the results of the TLC plate were visible using 254 nm and 366 nm UV light. Based on these results, it can be concluded that the extraction carried out on ginger simplicia was successful.
Copyright (c) 2023 Lalu Busyairi Muhsin, Muh. Eka Putra Ramandha http://creativecommons.org/licenses/by-sa/4.0
Analysis of Vitamin C Content of Lime (Citrus aurantifolia Swing.) and Sweet Orange (Citrus sinensis) using Iodometric Titration
Vitamins are a class of organic compounds that have a very important role for growth, maintenance of health, and other bodily functions so that the metabolism runs normally. There are lots of vitamins both of natural origin and those synthesized in the laboratory. One of them is vitamin C, this study aims to determine the levels of vitamin C (ascorbic acid) in samples of citrus fruit, lime and vitacimin by iodimetric titration. Redox titrations are titrations that involve oxidation and reduction processes. These two processes always occur simultaneously. In redox titrations usually use potentiometric to detect the end point. To determine vitamin C levels, the redox titration method used is direct titration using iodine. Iodine will oxidize compounds that have a smaller reduction potential than iodine. Based on the experiments conducted on the vitamin C test, it can be concluded that the determination of vitamin C levels by iodometric titration can be carried out on the principle of oxidation reduction. Vitamin C levels were obtained by iodometric titration method first which was carried out by diluting oranges, limes and vitamin C by 0.0006%, 0.0006287%, 0.000787%. In the second method without dilution, the concentration of vitamin C in oranges and limes is 0.03165%, 0.0 9%.
Copyright (c) 2023 Lalu Busyairi Muhsin http://creativecommons.org/licenses/by-sa/4.0
Etnofarmakologi dan Potensi Bioaktivitas Daun dan Buah Sirsak (Annona Muricata): Artikel Review
The leaves and fruit of soursop or Annona muracita have been used extensively as medicinal plants by people in various ethnic groups in Indonesia. Soursop leaves and fruit are believed to prevent and treat diabetes, obesity, and hypertension. Various scientific studies have proven the potential activity of soursop leaves and fruit to have antidiabetic, antioxidant, antiobesity, cytotoxic, anticancer, antihypertensive, antibacterial, anti-inflammatory, antirheumatic, and hepatoprotective effects. Based on literature studies related to phytochemicals sourced from Scopus, Science direct, PubMed, ProQuest reports that at least 54 secondary metabolites have been isolated and identified. These compounds include a group of alkaloids, phenols, and acetogenins. This article presents a brief overview that seeks to compile all information regarding the phytochemistry, ethnopharmacology, and bioactivity of soursop leaves and fruit.
Annona muracita, Bioaktivitas, Etnofarmakologi, Sirsak
Copyright (c) 2025 Eka Nurul Qomaliyah http://creativecommons.org/licenses/by-sa/4.0
Anemia Megaloblastik: Sebuah Tinjauan Pustaka
Anemia megaloblastik merupakan anemia yang ditandai dengan membesarnya eritroblast di sumsum tulang sehingga menganggu pematangan inti sel dan pembelahan sel eritrosit. Kelainan utamanya disebabakan karena defisiensi vitamin B-12 dan asam folat sehingga sintesis DNA terganggu. Diagnosis anemia megaloblastik dilakukan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pengobatannya dilakukan berdasarkan etiologi yang mendasari. Semakin cepat didiagnosis, prognosisnya akan semakin baik. Penting untuk mengenali, mencegah, dan mengobati anemia megaloblastik.
Anemia Megaloblastik Vitamin B-12 Asam Folat
Copyright (c) 2025 I Ketut Wisnuaji Jayawardhana, I Nyoman Bagus Aji Kresnapati http://creativecommons.org/licenses/by-sa/4.0
Chemical Quality Characteristics of White Rice (Oryza sativa) Facial Mask Lo'i Monca Traditional Dompu
People in Dompu Regency West Nusa Tenggara have always used traditional face mask products, namely masks lo'i monca which protect facial skin from the sun when they are active all day outdoors. Dompu traditional masks (lo'i monca) are made from rice, tamarind shoots, bangle, curcuma, temugiring, and galangal. The purpose of this study was to determine the chemical quality of facial masks in lo'i monca terms of pH, water content and antioxidants. This type of research is a type of laboratory experimental research. Based on the results of laboratory tests, the average pH value obtained by the face mask powder preparation lo'i monca is 7.08. In testing the water content, the average value of the powder mask preparation lo'i monca was 13.3%. The results of the IC50 antioxidant activity test for powder mask preparations lo'i monca were 14.47 ppm. The results of laboratory tests that meet the requirements are pH levels because the pH value is in the range of 4.5-8.0, while the results on the water content do not meet the SNI requirements because the water content value is more than 10%, and the results of the antioxidant activity test the IC50 value of mask preparations.powder is lo'i monca classified as a very strong antioxidant because it is at an IC50 value of less than 50 ppm.
asker Wajah, lo’i monca, kadar air antioksidan
Copyright (c) 2025 Tri Wahyudi N Kamagi, Devi Tanggasari http://creativecommons.org/licenses/by-sa/4.0
Aktivitas Antioksidan Ekstrak Metanol dan Fraksi N-Heksan-Etil Asetat Buah Paprika Merah (Capsicum annuum L.)
Buah paprika merah (Capsicum annuum L.) mengandung diantaranya adalah vitamin E, vitamin C, karotenoid, dan kapsaisinoid yang dapat digunakan sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan pada ekstrak metanol dan fraksi n-heksan-etil asetat buah paprika merah. Buah paprika merah segar diekstraksi dengan metode maserasi menggunakan pelarut metanol teknis kemudian difraksinasi secara bertingkat menggunakan pelarut n-heksan-dietil eter, hasil fraksi tidak larut n-heksan-dietil eter kemudian difraksinasi kembali menggunakan pelarut n-heksan-etil asetat. Fraksi n-heksan-etil asetat diuji secara kualitatif terhadap senyawa karotenoid yaitu β-karoten dengan uji KLT menggunakan fase diam silika gel F254 dan fase gerak metanol: aseton (1:1). Uji kuantitatif aktivitas antioksidan dilakukan dengan metode penangkapan radikal DPPH dengan parameter nilai IC50. Nilai IC50 selanjutnya dianalisis dengan menggunakan SPSS versi 20. Hasil uji kualitatif menunjukkan bahwa ekstrak metanol dan fraksi n-heksan-etil asetat mengandung senyawa β-karoten. Aktivitas antioksidan ekstrak metanol, fraksi n-heksan-etil asetat, dan standar β-karoten memiliki nilai IC50 berturut-turut sebesar 307,91, 281,69, dan 81,26 μg/mL. Berdasarkan hasil statistik, nilai IC50 fraksi n-heksan-etil asetat lebih kecil signifikan apabila dibandingkan dengan ekstrak metanol buah paprika merah. Namun lebih besar apabila dibandingkan dengan standar β-karoten. Fraksi n-heksan-etil asetat memiliki aktivitas antioksidan yang lebih poten apabila dibandingkan dengan ekstrak metanol buah paprika merah. Namun kurang poten apabila dibandingkan dengan standar β-karoten.
Antioksidan, Capsicum annuum L., DPPH, Paprika merah, Fraksi nheksan-etil asetat, Ekstrak metanol
Copyright (c) 2025 Nur Anisah, Warsi Warsi, Muhammad Eka Putra Ramandha, Widani Darma Isasih, Rizqa Inayati, Nurul Indriani http://creativecommons.org/licenses/by-sa/4.0