Evaluation of the Level of Medication Adherence of Antiepileptic Drugs (AEDs) on Cognitive Function of Children
Keywords:
Anti-epileptic drugs, children, cognitive function, medication adherence
Abstract
Epilepsy is a chronic brain disorder with various causes characterized by recurrent attacks. Epilepsy can affect all ages, including children, which affects around 40%-50%. Epilepsy can have an impact on memory disorders, either caused by symptoms of epilepsy itself, antiepileptic drugs (AEDs), psychosocial factors, or comorbidities. Patients with epilepsy are generally advised to consume AEDs for more than 3 months. This antiepileptic treatment takes a long time, so it is very susceptible to causing patient non-compliance in taking AEDs. Therefore, this study aims to determine the level of compliance of pediatric epilepsy patients and whether there is a relationship between compliance and the cognitive function of pediatric patients. In this study, 54 respondents were used from the Mataram City Hospital polyclinic. Compliance was measured using the Morisky Medication Adherence Scale 8 item (MMAS-8) questionnaire and cognitive function measure using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina). The result based on the MMAS-8 shows that 7.4% of respondents had high compliance, 61.1% had moderate compliance, and 31.5% had low compliance. Data analysis used the Chi-Square test with α = 0.01 and obtained a significance value (p-value = 0.329). Based on these results, it can be concluded that the level of compliance is moderate, and there is no relationship between compliance and cognitive function.
References
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Alwahdy, A. S., Budikayanti, A., Octaviana, F., & Hamid, D. (2020). Interaksi Hormon Dan Epilepsi. Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia, 37(2). https://doi.org/10.52386/neurona.v37i2.115
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Chamidah, A. N. (2017). Manajemen Epilepsi di Sekolah. Journal Universitas Negri Yogyakarta. https://doi.org/https://doi.org/10.21831/jpk.v13i2.19132
Dewi, N. P. (2020). Analisis Pola Penggunaan Obat Antiepilepsi di Instalasi Rawat Inap Rumah Sakit Umum Daerah Madani Propinsi Sulawesi Tengah. 5(1), 12–18. https://doi.org//10.55093/jurnalfarmaku.v5i1.103
Elsayed, M. A., El-Sayed, N. M., & dan Ahmed, M. H. (2017). Universal Health Coverage ‑ There is More to It Than Meets The Eye. Journal of Family Medicine and Primary Care, 6(2), 169–170. https://doi.org/10.4103/jfmpc.jfmpc
Fatmi, Kartika, Nurul., Dyan, Roshinta, Laksmi Dewi., Muhammad, In’am, Ilmiawan. (2022). Hubungan Lama Menderita, Frekuensi Kejang Dan Keteraturan Konsumsi Oae Terhadap Fungsi Kognitif Pada Pasien Epilepsi. Jurnal Nasional Ilmu Kesehatan,4(3), 52-65. https://doi.org/10.2621/jnik
Furaida, F. N., Julia, M., & Triono, A. (2022). Hubungan Durasi Terapi Asam Valproat dengan Kadar Asam Folat Darah pada Epilepsi Anak. Sari Pediatri, 24(4), 253. https://doi.org/10.14238/sp24.4.2022.253-8
Gunawan, D. P., Winifred, K., & S, J. M. P. (2014). Gambaran Tingkat Pengetahuan Masyarakat Tentang Epilepsi di Kelurahan Mahena Kecamatan Tahuna Kabupaten Sangihe. https://doi.org/https://doi.org/10.35790/ecl.v2i1.3856
Harahap, H. S., Indrayana, Y., & Amalia, E. (2017). Pola Pengobatan dan Fungsi Kognitif Pasien Epilepsi di RSJ Mutiara Sukma Treatment Pattern and Cognitive Function in Epilepsy Patients in Mutiara Sukma Mental Hospital. Jurnal Kedokteran Brawijaya, 29(4), 336. https://doi.org/https://doi.org/10.21776/ub.jkb.2017.029.04.9
Holmes, G. L. (2017). Cognitive impairment in Epilepsy: The Role of Network Abnormalities. Physiology & Behavior, 176(1), 100–106. https://doi.org/10.1177/0022146515594631.Marriage
Karyarini, E., Fatmawati, A., & Mawaddah, N. (2019). Hubungan Dukungan Keluarga Dengan Tingkat Kemandirian Pada Pasien Epilepsi Di Klinik Neurologi RSJ Dr. Radjiman Wediodiningrat Lawang Malang. Konferensi Nasional XVI, 3, 87–93. https://doi.org//KJ.2019.1018
Khansa, A. N., Laksmi Dewi, D. R., & Ilmiawan, M. I. (2022). Hubungan Usia Onset dengan Fungsi Kognitif Pasien Epilepsi di RSUD dr. Soedarso Kota Pontianak, Indonesia. Cermin Dunia Kedokteran, 49(11), 604–609. https://doi.org/10.55175/cdk.v49i11.313
Lestari, N. D., Hastuti, S., & Astini, N. (2023). Hubungan Lama Pengobatan dan Jenis Obat Antiepilepsi dengan Efek Samping Obat pada Pasien Epilepsi di Poliklinik Neurologi RSUDZA. Journal of Medical Science, 3(2), 80–87. https://doi.org/10.55572/jms.v3i2.98
Lukas, A., Harsono, & Astuti. (2016). Gangguan Kognitif pada Epilepsi. Berkala Ilmiah Kedokteran Duta Wacana, 01, 144–152. https://doi.org/https://doi.org/10.21460/bikdw.v1i2.10
Mangunatmadja, I., Mulyani, D. I., Pardede, S. O., Tridjadja, B., & Wulandari, H. F. (2019). Faktor Risiko Epilepsi Intraktabel pada Anak dengan Epilepsi Umum. 69(2), 59–65. https://doi.org//10.692/JIM.2019.2802
Mawuntu, A. H. ., Corry, N. M., Sekplin, A. S. S., Karema, W., & Herlyani, K. (2019). Kepatuhan Minum Obat Antiepilepsi pada Pasien Epilepsi di Manado, Indonesia. 2(3). https://doi.org/10.35790/ecl.5.2.2017.185
Perwitasari, L., Nugroho, H. W., & Nur, F. T. (2023). Hubungan Tipe Serangan Epilepsi pada Anak Dengan Penurunan Fungsi Kognitif di RSUD Dr. Moewardi. Plexus Medical Journal, 2(3), 109–121. https://doi.org/10.20961/plexus.v2i3.566
Ramdaniah, P., Ningrum, M. D., Yuliana, D., Eka, D., & Bimmahariyanto, S. (2022). Studi Adverse Drug Reactions Penggunaan Obat Antiepilepsi Monoterapi pada Anak di Rumah Sakit - Studi Farmakovigilans. 3(2), 355–359. https://doi.org/2715-5277
Sari, P. R. P. G., Mahalini, D. S., Hartawan, I. N. B., & Wati, D. K. (2023). Tingkat Kualitas Hidup Pasien Anak Epilepsi Dengan QOLCE-16. Intisari Sains Medis, 14(3), 1249–1253. https://doi.org/10.15562/ism.v14i3.1908
Setiani, L. A., Almasyhuri, & Hidayat, A. A. (2022). Evaluasi Kepatuhan Pasien pada Penggunaan Obat Antidiabetik Oral Dengan Metode Pill-Count dan MMAS-8 di Rumah Sakit PMI Kota Bogor. Jurnal Ilmiah Ilmu Terapan Universitas Jambi, 6(1), 32–46. https://doi.org/https://doi.org/10.22437/jiituj.v6i1.19329
Sigar, R. J., Kembuan, M. A. H., & Mahama, C. N. (2017). Gambaran Fungsi Kognitif pada Pasien Epilepsi di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado. E-CliniC, 5(2). https://doi.org/10.35790/ecl.5.2.2017.18582
Suwarba, I. G. N. M. (2016). Insidens dan Karakteristik Klinis Epilepsi pada Anak. Sari Pediatri, 13(2), 123. https://doi.org/10.14238/sp13.2.2011.123-8
Utami, T. M., Halim, W., Handriyati, A., Kedokteran, P. S., Kedokteran, F., & Alkhairaat, U. (2024). Karakteristik Penderita Epilepsi pada Anak di RSU Anutapura Palu. 5(April), 387–394. https://doi.org/https://doi.org/10.31970/ma.v6i1.179
World Health Organization (WHO).2024. Epilepsy Fact Sheets. Diunduh dari https://www.who.int/news-room/fact-sheets/detail/epilepsy
Published
2024-10-29
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Articles
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