The Effect of Variations in HPMC and Carbopol Bases on The Physical Stability of Okra (Abelmoschus esculentus L.) Fruit Gel Formulations
Keywords:
Abelmoschus esculentus, Gel, HPMC, Karbopol
Abstract
Okra fruit (Abelmoschus esculentus L.) is a vegetable that is often used as medicine. Okra fruit contains flavonoids which are antioxidants. Gel formulation with a concentration of 5%, and various combinations of HPMC and carbopol bases. This research aims to determine the physical stability of gel preparations and the effect of variations in the concentration of gelling ingredients in the preparations. The gel formulation consists of 4 formulas, namely F0, F1, F2, and F3. Physical stability tests include organoleptic tests (odor, color and texture), homogeneity, pH, spreadability, stickiness, viscosity and synergy. Tests were carried out for 14 days of storage, namely on days 1, 3, 5, 7, and 14 at room temperature (25℃). The observation results showed that in the organoleptic test there was no change in color, odor and texture in the gel preparation during 14 days of storage. The four gel formulas are homogeneous and there is no synergy. Variations in the combination of HPMC and carbopol bases affect the physical properties of the gel, including pH, viscosity, spreadability and adhesion. HPMC and Carbopol affect the pH of the preparation, the higher the Carbopol content and the lower the HPMC content, the more acidic it is. Carbopol and HPMC affect the values of spreadability, viscosity and adhesion because the higher the concentration of carbopol and HPMC produces a thick gel preparation so that the spreadability decreases, viscosity increases and adhesion also increases.
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Shastri, D., Prajapati, S., & Patel, L. (2010). Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers. Acta Pharmaceutica, 60(3), 349–360. https://doi.org/10.2478/V10007-010-0029-4
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Buzea, C., Pacheco, I. I., & Robbie, K. (2007). Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases, 2(4), MR17–MR71. https://doi.org/10.1116/1.2815690
Distiani, N. T. (2021). Optimasi Gel Ekstrak Etanol Daun Sawo Manila (Manilkara zapota L) Dengan Kombinasi Na-Cmc Dan Carbopol Serta Uji Aktivitas Terhadap Pertumbuhan Staphylococcus aureus. Repository Perpustakaan STIKES Nasional, 14 Apr 2022.
Djamal, J. M., Farida, N., Sabaan, W., & Trinovitasari, Y. (2020). Formulasi Krim Ekstrak Etanol Herba Patah Tulang ( Euphorbia tirucalli l ) 10 % Dengan Variasi Nilai Hlb Tween 80 Dan Span 80 Sebagai Emulsifying Agent. Jurnal Ilmu Farmasi, I(2), 10–14.
Estikomah, S. A., Amal, A. S. S., & Safaatsih, S. F. (2021). Formulasi Sediaan Gel Semprot Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Dan Uji Daya Hambat Terhadap Bakteri Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes. Pharmaceutical Journal of Islamic Pharmacy, 5(1), 36. https://doi.org/10.21111/pharmasipha.v5i1.5705
Faisal, H., Sastra, H., Andry, M., Sari, M., Chan, A., & Nasution, M. A. (2023). Toothpaste formulation of ethanol extract of takokak fruit (Solanum torvum Sw.) and yellowfin tuna (Thunnus albacares) bone against Streptococcus viridans bacteria and Escherichia coli bacteria. Journal of Pharmaceutical and Sciences, 6(3), 1322–1338. https://doi.org/10.36490/JOURNAL-JPS.COM.V6I3.218
Fernanda, D. P., Firman, R., & Ranny, P. (2022). Uji Aktivitas Dan Formulasi Sediaan Liquid Body Wash Dari Ekstrak Etanol Bunga Telang (Clitoria ternatea L) Sebagai Antibakteri Staphylococcus epidermidis. Jurnal Ilmiah Kedokteran Dan Kesehatan, 1(1), 53–66. https://doi.org/10.55606/klinik.v1i1.257
Hendri Faisal, & Handayani, S. (2019). Comparison of Antioxidant Activity of Ethanol Extract of Fruit and Okra Leaves (Abelmoschus esculentus L. Moench) with DPPH and ABTS Methods. Indonesian Journal of Pharmaceutical and Clinical Research, 2(2), 6–13. https://doi.org/10.32734/idjpcr.v2i2.2815
Hidayat, I. R., Zuhrotun, A., & Sopyan, I. (2021). Design-Expert Software sebagai Alat Optimasi Formulasi Sediaan Farmasi. Majalah Farmasetika, 6(1), 99–120. https://doi.org/10.24198/MFARMASETIKA.V6I1.27842
Hidayatul, F., Efendi, I., & Na’imah, J. (2023). Formulasi dan Uji Stabilitas Fisik Gel Piroxicam Sebagai Pengobatan Nyeri Pasca Trauma Berbasis Carbomer. Pharmauho: Jurnal Farmasi, Sains, Dan Kesehatan, 9(1). https://doi.org/10.33772/pharmauho
Idrus, I., Kurniawan, F., Mustapa, F., & Wibowo, D. (2021). Concentration Effect of Leaf Extract from Kekara Laut (Canavalia Maritima Thou.) in inhibiting of Staphylococcus Epidermidis Bacteria with a Statistical Science Approach. Indo. J Chem. Res., 8(3), 180–185. https://doi.org/10.30598//ijcr.2021.8-irm
Irianto, I. D. K. (2021). Formulasi Dan Uji Stabilitas Fisik Sediaan Gel Sampo Minyak Atsiri Biji Pala (Myristica fragrans). Jurnal Jamu Kusuma, 1(1), 27–35. https://doi.org/10.37341/jurnaljamukusuma.v1i1.4
Khoirotuzzahra, A., Kendal, S., Fajaryanti, N., Mediastini, E., & Pitarisa, A. P. (2023). Perbandingan Konsentrasi HPMC Terhadap Stabilitas Fisik Sediaan Gel Ekstrak Etanol Daun Sirsak (Annona Muricata L.). Journal Clinical Pharmacy and Pharmaceutical Science, 2(1), 82–95.
Kurniawati, P. (2020). Uji Kualitas HPMC (Hidroksi Propil Metil Selulosa) sebagai Bahan Baku Produk Berbasis Gel di PT. Konimex Pharmaceuticals Laboratories.
Lianisanti, E. (2021). Uji Formulasi Dan Stabilitas Sediaan Gel Hand Sanitizer Dari Air Perasan Buah Jeruk Nipis (Citrus aurantifolia Swingle) Berbasis Karbopol 940 Dan HPMC. March, 1–19.
Mardiah, H. D. (2023). Evaluasi fisikokimia formula sabun cair pembersih tangan dengan kandungan ekstrak etanol daun petai cina: Leucaena leucocephala (Lam.) de Wit.
Noviardi, H., Ratnasari, D., & Fermadianto, M. (2019). Formulasi Sediaan Krim Tabir Surya dari Ekstrak Etanol Buah Bisbul (Diospyros blancoi). Jurnal Ilmu Kefarmasian Indonesia, 17(2), 262. https://doi.org/10.35814/jifi.v17i2.771
Nurjannah, E. (2021). Pengaruh Pemberian Puding Okra (Abelmpschus Esculentus) Terhadap Perubahan Kadar Glukosa Darah Usia Dewasa. In E-Prints.
Nurlely, N., Rahmah, A., Ratnapuri, P. H., Srikartika, V. M., & Anwar, K. (2021). Uji Karakteristik Fisik Sediaan Gel Ekstrak Daun Kirinyuh (Chromolaena odorata L.) dengan Variasi Karbopol dan HPMC. Jurnal Pharmascience, 8(2), 79. https://doi.org/10.20527/jps.v8i2.9346
Pogaga, E., Yamlean, P. V. Y., & Lebang, J. S. (2020). Formulasi Dan Uji Aktivitas Antioksidan Krim Ekstrak Etanol Daun Murbei (Morus alba L.) Menggunakan Metode DPPH (1,1-Diphenyl-2-Picrylhydrazyl). PHARMACON, 9(3), 349. https://doi.org/10.35799/pha.9.2020.30018
Purwanto, A., & Zamzani, I. (2020). Formulation Of Antioxidant Gel From Green Tea Leaves (Camellia sinensis L.) Using Combination Of Polymer Methyl Cellulosa And Carbopol 940 AS. In JCPS.
Puteri, D. H. (2019). Analisis Aktivitas Antioksidan, Serat dan Daya Terima Puding Okra Hijjau (Abelmoschus Esculantus L.) Dengan Penambahan Kedelai (Glycine max). 111.
Shastri, D., Prajapati, S., & Patel, L. (2010). Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers. Acta Pharmaceutica, 60(3), 349–360. https://doi.org/10.2478/V10007-010-0029-4
Silva, M. B. (2016). Percepção da população assistida sobre a inserção de estudantes de medicina na Unidade Básica de Saúde. Trabalho de Conclusão de Curso, 1(9), 1–10. https://doi.org/10.1017/CBO9781107415324.004
Sukmadewi, E. (2019). Pengaruh Ekstrak Buah Tin (Ficus carica L.) Sebagai Antioksidan Terhadap Gambaran Histopatologi Glomerulus Mencit yang Dipapar Rhodamin B. Journal of Chemical Information and Modeling, 53(9), 1689–1699.
Wicaksono, M. R. (2019). Formulasi Dan Uji Stabilitas Fisik Sediaan Gel Semprot Kombinasi Ekstrak Daun Mangkokan (Polyscias scutellaria) Daun Waru (Hibiscus tiliaceus Linn.) Dengan Karbopol Dan Hidroksi Propil Metil Selulosa (Hpmc) Sebagai Gelling Agen. Progress in Retinal and Eye Research, 561(3), S2–S3.
Published
2023-10-31
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Articles
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