Analysis of Side Effects of Corona Virus Disease-19 (COVID-19) Vaccine Booster Usage on Healthcare Workers

  • Handini Mulianti Universitas Bumigora
  • Muhammad Isnaini Zuhri Universitas Bumigora
  • Widani Darma Isasih Universitas Bumigora
Keywords: Booster, Covid 19 Vaccine, Moderna, Side effect

Abstract

The Coronavirus Disease 2019 (COVID-19) is an infectious condition caused by the SARS-CoV-2 virus. This virus has undergone mutations, leading to new variants that have contributed to the increase in COVID-19 cases. Governments have initiated vaccination efforts as part of their strategies to curb the spread, particularly among healthcare workers. However, concerns have arisen regarding the occurrence of post-vaccination side effects. The objective of this study is to identify and categorize the side effects that arise after administering the COVID-19 (booster) vaccine, specifically the Moderna COVID-19 Vaccine®. The study employs a cross-sectional approach, collecting data through interviews and questionnaire completion among medical staff at Puskesmas Santong in April 2023. The study's findings reveal that out of 69 respondents, 94.2% experienced side effects following vaccination, while 5.8% did not encounter any. The majority of these side effects fall into the "probable" category (69.6%) according to the Naranjo Scale Algorithm. Common systemic side effects include fever (60.9%), dizziness (43.5%), fatigue (33.3%), muscle aches (31.9%), joint pain (13%), chills (11.6%), headache (10.1%), nausea (4.3%), runny nose (1.4%), and sneezing (1.4%). Local side effects, such as injection site pain, were reported by 34.8% of the respondents. The majority of these side effects persisted for 2 days (42%).

References

Antonelli M, Penfold RS, Merino J, Sudre CH, Molteni E, Berry S, Canas LS, Graham MS, Klaser K, Modat M, Murray B, Kerfoot E, Chen L, Deng J, Osterdahl MF, Cheetham NJ, Drew DA, Nguyen LH, Pujol JC, Hu C, Selvachandran S, Polidori L, May A, Wolf J, Chan AT, Hammers A, Duncan EL, Spector TD, Ourselin S, Steves CJ. (2022). Risk Factors and Disease Profile Of Post-Vaccination SARS-CoV-2 Infection In UK Users Of The COVID Symptom Study App: A Prospective, Community-Based, Nested, Case-Control Study. The Lancet Infection. 22:43-55. Doi:https://dx.doi.org/10.1016/S1473-3099(21)00460-6.
Al-Qazaz HK, Al-Obaidi LM, dan Attash HM. (2022). COVID-19 Vaccination, Do Women Suffer From More Side Effects Than Men? A Retrospective Cross-Sectional Study. Pharmacy Practice. 20(2):1-6. Doi: https://doi.org/10.18549/PharmPract.2022.2.2678.
Centers for Disease Control and Prevention (CDC). (2022). The Moderna COVID-19 Vaccine’s Local Reactions, Systemic Reactions, Adverse Events, and Serious Adverse Events. Available at. https://www.cdc.gov/vaccines/covid-19/info-byproduct/moderna/reactogenicity.html [diakses pada 10 Agustus 2023].
Chadwick A, Johannes K, Vaccari C, Freeman D, Lambe S, Loe BS, Vanderslott S, Lewandowsky S, Conroy M, Ross ARN, Innocenti S, Pollard AJ, Larkin FWM, Rosebrock L, Jenner L, McShane H, Giubilini A, Petit A, & Yu LM. (2021). Online Social Endorsement and COVID-19 Vaccine Hesitancy In The United Kingdom. SAGE Journal. 7(2). doi: https://doi.org/10.117/20563051211008817.
Gianfredi V, Minerva M, Casu G, Capraro M, Chiecca G, Gaetti G, Mazzocchi RM, Musaro P, Basteri P, Bertini B, Ferri C, Odone A, Signorelli C, Alberti VF, & Gastaldi G. (2021). Immediate Advers Ivents Following COVID-19 Immunezation. A Cross-Sectional Study Of 314,661 Italian Subjects. Acta Biomed. 92(6):1-7. Doi: https://dx.doi.org/10.23750/abm.v92iS6.12365.
Idayanti N, Sutiningsih D, Hadi MM, Abrori I.(2021). Adverse Effects Associated With Third-Booster COVID-19 Vaccine (Heterologous Vaccine By Sinovac-Moderna) Among Health Care Workers. International Journal Of English Literature And Social Sciences. 6(6):250-252. Doi: https://dx.doi.org/10.22161/ijels.66.39.
Kadali RAK, Janagama R, Peruru S, Gajula V, Madathala RR, Chennaiahgari N, Malayala SV. (2021). Non‐Life‐Threatening Adverse Effects With COVID‐19 mRNA‐1273 Vaccine: A Randomized, Cross‐Sectional Study On Healthcare Workers With Detailed Self‐Reported Symptoms. Medical Virology. 93:4420-4429 Doi: https://doi.org/10.1002/jmv.26996.
Kementrian Kesehatan Republik Indonesia. (2020). Pedoman Kesiapsiagaan Menghadapi Infeksi Novel Coronairus (2019-nCoV). Jakarta: Direktorat Jenderal Pencegahan dan Pengendalian Penyakit.
Kementrian Kesehatan Republik Indonesia. (2022). Surat Edaran Nomor HK.02.02/11/252/2022 Tentang Vaksinasi COVID-19 Dosis Lanjutan (Booster). Jakarta: Kementrian Kesehatan Republik Indonesia.
Kementrian Kesehatan Republik Indonesia. (2022). Vaksinasi COVID-19 Nasional. Available at: https://vaksin.kemkes.go.id/#/vaccines. [Diakses 15 Desember 2022].
Kurniawati D, dan Yuwindry I. (2023). Pengaruh Tingkat Pengetahuan Mahaiswa Terhadap Efek Samping Vaksinasi COVID-19 di Universitas Sari Mulia. Journal Of Pharmaceutical Care and Sciences. 3(2):141-155.
Lidia T, dan Widayati A. (2021). Study Of Corona Disease 2019 (COVID-19) Vaccination In Indonesia: A Literature Review. Jurnal Farmasi Sains dan Komunitas. 18(2):65-77. Doi: https://doi.org/10.24071/jpsc.003459.
MacDonald NE. (2015). Vaccine Hesitancy: Definition, Scope and Determinants. Vaccine. 33:4161-1264. Doi: https://doi.org/10.1016/j.vaccine.2015.04.036.
Menni C, Klaser K, May A, Polidori L, Capdevila J, Louca P, Sudre CH, Nguyen LH, Drew DA, Merino J, Hu C, Selvachandran S, Antonelli M, Murray B, Canas LS, Molteni A, Graham MS, Modat M, Joshi AD, Mangino M, Hammers A, Goodman AL, Chan AT, Wolf J, Steves CJ, Valdes AM, Ourselin S, & Spector TD. (2021). Vaccine Side-Effects And Sars-Cov-2 Infection After Vaccination In Users Of The Covid Symptom Study App In The Uk: a Prospective Observational Study. Thelancet. 21:939-949. Doi: https://doi.org/10.1016/ S1473-3099(21)00224-3.
Mohsin M, Mahmud S, Mian AU, Hasan P, Muyeed A, Ali MT, Ahmed FF, Islam A, Rahman MM, Islam M, Khan MHR, Rahman MS. (2022). Side Effects Of COVID-19 Vaccines and Perceptions About COVID-19 and Its Vaccines In Bangladesh: A Cross-Sectional Study. Vaccine: X. Doi: https://doi.org/10.1016/j.jvacx.2022.100207.
MSKCC (Memorial Sloan Kettering Cancer Center). (2021). Information For Msk Receiving The Moderna COVID-19 Vaccine. New York: MSKCC.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. (1981). A Method For Estimating The Probability Of Adverse Drug Reactions. Clinical Pharmacology Ther. 30(2):239-245.
Rosylin L, Guntur, Khairina F, Yustriani L. (2022). Vaksinasi COVID-19 di Indonesia. Jakarta: Kementerian Koordinator Bidang Perekonomian.
Pakki TR, Mariana N, Tampubolon ML, Rusli A, Romadhona S, Intan AD, Chohan Z, Widiantari AD, Herlina H, Puspitasari A, Mahardika M, Sulianti S, Maemun S, Murtiani, dan F. Syahril M. (2022). Side Effects After mRNA COVID-19 Vaccine As A Booster In Health Workers. Iran J Public Health. 51(11):2504-2509.
World Health Organization (WHO). (2020). WHO Director-General’s Opening Remarks At The Media Briefing on COVID-19- 11 March 2020. Available at: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-2019-11-march-2020 [Diakses 12 Agustus 2023].
World Health Organization (WHO). (2022). Pertanyaan dan jawaban terkait Coronavirus. Available at: https://www.who.int/indonesia/news/novel-coronavirus/qa/qa-for-public [Diakses 12 Agustus 2022].
World Health Organization (WHO). (2022). Tanya Jawab: Penyakit corona virus (COVID-19) - vaksin. Available at: https://www.who.int/indonesia/news/novel-coronavirus/qa/qa-covid-19-vaksin [Diakses 10 Agustus 2023].
Published
2023-10-31