Etnofarmakologi dan Potensi Bioaktivitas Daun dan Buah Sirsak (Annona Muricata): Artikel Review
Keywords:
Annona muracita, Bioaktivitas, Etnofarmakologi, Sirsak
Abstract
The leaves and fruit of soursop or Annona muracita have been used extensively as medicinal plants by people in various ethnic groups in Indonesia. Soursop leaves and fruit are believed to prevent and treat diabetes, obesity, and hypertension. Various scientific studies have proven the potential activity of soursop leaves and fruit to have antidiabetic, antioxidant, antiobesity, cytotoxic, anticancer, antihypertensive, antibacterial, anti-inflammatory, antirheumatic, and hepatoprotective effects. Based on literature studies related to phytochemicals sourced from Scopus, Science direct, PubMed, ProQuest reports that at least 54 secondary metabolites have been isolated and identified. These compounds include a group of alkaloids, phenols, and acetogenins. This article presents a brief overview that seeks to compile all information regarding the phytochemistry, ethnopharmacology, and bioactivity of soursop leaves and fruit.
References
Adewole S.O., Caxton-Mar tins E.A. 2006. Morphological changes and hypoglycemic effects of Annona muricata Linn.(annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats. Afr J Biomed Res.9(3):173-187
Adewole, S. and Ojewole, J. 2009. Protective effects of Annona muricata Linn.(Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats'. African journal of traditional, complementary and alternative medicines. 6(1).
Adeyemi D., Komolafe O., Adewole O., Obuotor E., Abiodun A., Adenowo T.
2010. Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata. Folia Morphol. 69(2):92-100.
Adeyemi D., Komolafe O., Adewole S., Obuotor E. 2009. Anti hyperlipidemic activities of Annona muricata (Linn). Internet J Altern Med. 7(1):1-7
Adeyemi DO, Komolafe OA, Adewole OS, Obuotor EM, Adenowo TK. Antihyperglycemic activities of Annona muricata (Linn). Afr. J Tradit Complement Altern Med. 2009; 6:62-69
Adeyemi DO, Komolafe OA, Adewole SO, Obuotor EM, Adenowo TK. 2008. Effects of Annona muricata (Linn) on the morphology of pancreatic islet cells of experimentallyinduced diabetic wistar rats. Internet J Altern Med. 5:2
Agbai E., Mounmbegna P., Njoku C., Nwanegwo C., Awemu G., Iwuji S. 2015. Effect
of Annona muricata seed extract on blood glucose, total and differential white cell count after repeated exposure to clozapine. Res Neurosci. 4(1):10-15.
Agu KC, Okolie PN. 2017. Proximate composition, phytochemical analysis, and in vitro antioxidant potentials of extracts of Annona muricata (Soursop). Food Sci Nutr. 5:1029–1036. https://doi.org/10.1002/fsn3.498 20487177.
Algeryani, Safa A., Najwa F. A, Shwihdy, Ruwida M. K. Omar, Nouha El-shinitri, Radwan A. Alnajjar. 2020. Review of Biological Properties, Composition and Toxicity of Annonna Muricata. The Scientific Journal of University of Benghazi Medical Sciences. 33(1): 5 – 10.
Alonso-Castro, A.J., Villarreal, M.L., Salazar-Olivo, L., GomezSanchez, M., Dominguez, F., Garcia-Carranca, A. 2011. Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and etnobotanical studies. J. Ethnopharmacol. 133, 945–972
Ana V. Coria-Te´ llez, Efigenia Montalvo-Go´ nzalez, Elhadi M. Yahia,
Eva N. Obledo-Va´ zquez. 2016. Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry.
Ani, Novi, Sukenti, Kurniasih, Aryanti, Evy, Rohyani , Immy Suci. 2021. Ethnobotany Study of Medicinal Plants by the Mbojo Tribe Community in Ndano Village at the Madapangga Nature Park, Bima, West Nusa Tenggara. Jurnal Biologi Tropis. 21 (2): 456 – 469.
Arthur, F.K., Woode, E., Terlabi, E., Larbie, C., 2012a. Bilirubin lowering potential of Annona muricata (Linn.) in temporary jaudiced rats. Am. J. Pharmacol. Toxicol. 7, 33–40. Arthur, F.K., Woode, E., Terlabi, E., Larbie, C., 2012b. Evaluation of hepatoprotetctive effect of aqueous extract of Annona muricata (Linn.) leaf against carbon tetrachloride and acetaminopheninduced liver damage. J. Nat. Pharm. 3, 25–30
Aversa, Raffaella and Petrescu, Relly Victoria and Apicella, Antonio and Petrescu, 2016. Florian Ion, One Can Slow Down the Aging Through Antioxidants. American Journal of Engineering and Applied Sciences, Volume 9, Issue 4 (2016), Available at SSRN: https://ssrn.com/abstract=3074497
Badrie N, Schauss AG. Soursop. 2010. (Annona muricata L.): Composition, Nutritional Value, Medicinal Uses, and Toxicology, Bioactive Foods in Promoting Health, Ch. 39:621-641.
Badrie, N., Schauss, A.G., 2009. Soursop (Annona muricata L.): composition, nutritional value, medicinal uses, and toxicology. In: Watson, R.R., Preedy, V.R (eds.), Bioactive Foods in Promoting Health. Oxford, pp. 621–643
Baskar, R., Rajeswari, V. and Kumar, T. S. 2007. In vitro antioxidant studies in leaves of Annona species'. Indian J Exp Biol. 45(5), pp. 480-5.
Bento, E.B., Matias, E.F.F., Brito, F.E., Oliveira, D.R., Coutinho, H.D.M., Costa, J.G.M., Kerntopf, M.R., Menezes, I.R.. 2013.Association between food and drugs: antimicrobial and synergistic activity of Annona muricata L. Int. J. Food Prop. 16 (4), 738–744
Berawi K.N., Shidarti L., Nurdin S.U., Lipoeto N.I., Wahid I. 2017. Comparison Effectiveness of Antidiabetic Activity Extract Herbal Mixture of Soursop Leaves (Annona muricata), Bay Leaves (Syzygium Polyanthum) and Pegagan Leaves (Centella Asiatica). Biomed Pharmacol J. 10(3):1481-1488
Boulogne, I., Germose´ n-Robineau, L., Ozier-Lafontaine, H., Fleury,M., Loranger Merciris, G., 2011. TRAMIL ethnopharmalogical survey in les Saintes (Guadeloupe, French West Indies): a comparative study. J. Ethnopharmacol. 133 (3), 1039–1050.
Bradacs, G., Heilmann, J., Weckerle, C.S., 2011. Medicinal plant use in Vanautu: a comparative ethnobotanical study of three islands. J. Ethnopharmacol. 137, 434–448.
Braguini, W.L., Pires, N.V. and Alves, B.B. 2018. Phytochemical Analysis, Antioxidant Properties and Brine Shrimp Lethality of Unripe Fruits of Solanum viarum. Journal of Young Pharmacists, 10(2).
Bussmann, R.W., Malca, G., Glenn, A., Sharon, D., Nilsen, B., Parris, B., Townesmith, A., 2010. Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies. J. Ethnopharmacol. 132: 101–108.
Champy, P., Gue´ rineau, V., Lapre´ vote, O., 2009. MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata products for human consumption. Molecules 14, 5235–5246.
Chang, F.R., Wu, Y.C., 2001. Novel cytotoxic Annonaceous acetogenins from Annona muricata. J. Nat. Prod. 64, 925–931.
Clarkson, C., Maharaj, V.J., Crouch, N.R., Grace, O.M., Pillay, P., Matsabisa, M. G.,Bhagwandin, N. Smith, P.J. and Folb, P.I. (2004). In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. Journal of Ethnopharmacology, 92(2-3), 177-191.
Coria-Téllez, A. V., Montalvo-Gónzalez, E., Yahia, E. M., & Obledo-Vázquez, E. N. (2018). Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry, 11(5), 662–691.
Daglia, M. 2012. Polyphenols as antimicrobial agents. Current Opinion in Biotechnology, 23(2): 174-181.
De Souza R, Benassi E, da Silva RR, Afonso S, Scarminio IS. Enhanced extraction yields and mobile phase separations by solvent mixtures for the analysis of metabolites in Annona muricata L. Leaves. J Sep Sci. 2009; 32:4176-4185.
De Souza, K., Tchacondo, T., Djikpo Tchibozo, M.A., AbdoulRahaman, S., Anani, K., Koudouvo, K., Batawila, K., Agbonon, A., Simpore, J., De Souza, C., 2011. Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the Central Region of Togo. Pharm. Biol. 49,
1286–1297
Ekor Martins. 2014. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology. 4 (177): 1-10. https://doi.org/10.3389/fphar.2013.00177.
Elekofehinti, O. O., Lawal, A. O., Ejelonu, O. C., Molehin, O. R., & Famusiwa, C. D. 2020. Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies. Journal of Diabetes and Metabolic Disorders. doi:10.1007/s40200-020-00491-7
Elfahmi E, Woerdenbag HJ, Kayser O. 2014. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med 4: 51-73. DOI: DOI: 10.1016/j.hermed.2014.01.002.
Ezirim A, Okachi V, James A, Adebeshi O, Ogunnowo S, Odeghe O. 2013. Induction of apoptosis in myelogenous leukemic k562 cells by ethanolic leaf extract of Annona muricata. Indian J Drug Dis. 2013; 2:142-151
Florence, N.T.; Benoit, M.Z.; Jonas, K.; Alexandra, T.; Desire, D.D.; Pierre, K.; Theophile, D. 2014. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats. J. Ethnopharmacol. 151: 784–790. [CrossRef] [PubMed]
Gajalakshmi S, Vijayalakshmi S And Devi Rajeswar. 2012. Phytochemical And Pharmacological Properties of Annona Muricata: A Review. Intenational journal of Pharmacy and Pharmaceutical science. 4(2).
George, V.C., Kumar, D.R., Rajkumar, V., Suresh, P.K., Ashok, K., 2012. Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. In normal and immortalized human cell lines. Asian Pac. J. Cancer Prev. 13, 699–704.
Hajdu, Z., Hohmann, J., 2012. An ethnopharmacological survey of the traditional medicine utilized in the community of Porvenir, Bajo Paraguay Indian Reservation, Bolivia. J. Ethnopharmacol. 139 (3), 838–857.
Hardoko Y.H., Wijoyo S., Halim Y. 2015. In vitro antidiabetic activity of “green tea” soursop
leaves brew through α-glucosidase inhibition. Int J PharmTech Res. 8(1):30-37.
Hasrat, J. A., De Bruyne, T., DE BACKER, J. P., Vauquelin, G., & Vlietinck, A. J. 1997. Isoquinoline derivatives isolated from the fruitof Annona muricata as 5‐HTergic 5‐HT1A receptor agonists in rats: unexploited antidepressive (lead) products. Journal of pharmacy and pharmacology. 49(11): 1145- 1149
Hosseinzadeh, Saleh, Azizollah Jafarikukhdan, Hosseini , Ahmadreza, Armand Raham. 2015. The Application of Medicinal Plants in Traditional and Modern Medicine: A Review of Thymus vulgaris. International Journal of Clinical Medicine. 6: 635-642.
J.O. Oluyege, P.I. Orjiakor, O.E. Badejo. 2019. Phytochemical screening and in vitro antimicrobial properties of Annona muricata extracts against certain human pathogens. Scientific Journals of the Maritime University of Szczecin. 60 (132), 203–209.
Jadid N, Kurniawan E, Himayani CES, Andriyani, Prasetyowati I, Purwani KI, Muslihatin W, Hidayati D, Tjahjaningrum ITD. 2020. An ethnobotanical study of medicinal plants used by the Tengger tribe in Ngadisari village, Indonesia. PLoS ONE 15(7): e0235886. DOI: 10.1371/journal.pone.0235886.
Jaramillo M, Arango G, Gonzalez M, Robledo S, Velez ID. 2000. Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia.71:183-186.
Jiménez VM, Gruschwitz M, Schweiggert RM, Carle R, Esquivel P. 2014. Identification of phenolic compounds in soursop (Annona muricata) pulp by high-performance liquid chromatography with diode array and electrospray ionization mass spectrometric detection. Food Res Int. 65:42-46.
Justino A.B., Miranda N.C., Franco R.R., Martins M.M., da Silva N.M.. 2008. Espindola
F.S. Annona muricata Linn. leaf as a source of antioxidant compounds with in
vitro antidiabetic and inhibitory potential against α-amylase, α-glucosidase, lipase,
non-enzymatic glycation and lipid peroxidation. Biomed Pharmacother. 100:83-92[CrossRef] [PubMed].
Kim GS, Zeng L, Alali F, Rogers LL, Wu FE, McLaughlin JL. 1998. Two new mono-tetrahydrofuran ring acetogenins, annomuricin e and muricapentocin, from the
leaves of Annona muricata. J Nat Prod.; 61:432-436.
Kim, G.-T., Cho, K.-H., Sharma, A., Devi, S., & Park, T.-S. 2021. Annona muricata leaf extract attenuates hepatic lipogenesis and adipogenesis. Food & Function, 12(10), 4621 4629. doi:10.1039/d1fo00509j
Kim GS, Zeng L, Alali F, Rogers LL, Wu FE, Sastrodihardjo S. 1998. Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata in honour of professor gh neil towers 75th birthday. Phytochemistry. 49:565-571.
Kuete, V., Mbaveng, A.T., Nono, E.C., Simo, C.C., Zeino, M., Nkengfack, A. E.and Efferth, T. 2016. Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells. Phytomedicine, 23(8): 856-863.
Langenberger, G., PriggeKonrad, V., Martin, K., Belonias, B. 2009. Ethnobotanical knowledge of Philippine lowland farmers and its application in agroforestry. Agrofor. Syst. 76: 173–1994
Leon-Fernandez AE, Sayago-Ayerdi SG, Velazquez-Estrada RM, Zepeda-Vallejo LG, Yahia E, Montalvo-Gonzalez E. 2017. In-vitro antioxidant capacity of crude extracts and acetogenin fraction of soursop fruit pulp. Pharmaceutica Analytica Acta. 8(6): 550 – 556. DOI: 10.4172/2153- 2435.1000550
Liaw, C.C., Chang, F.R., Lin, C.Y., Chou, C.J., Chiu, H., Wu, M.J., 2002. New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. J. Nat. Prod. 65: 470–476.
Melot, A., Fal, D., Gleye, C., Champy, P. 2009. Apolar annonaceous acetogenins from the fruit pulp of Annona muricata. Molecules. 14:4387–4395
Mishra S, Ahmad S, Kumar N, Sharma BK. 2013. Annona muricata (the cancer killer): A review. Glob. J Pharm Res. 2:1613-1618.
Moghadamtousi Soheil Zorofchian , Fadaeinasab Mehran , Nikzad Sonia, Mohan Gokula , Ali Hapipah Mohd and Abdul Kadir Habsah. 2015. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. International journal of molecular science. 16:15625-15658.
Moghadamtousi SZ, Kadir HA, Paydar M, Rouhollahi E, Karimian H. 2014. Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. BMC Complement Altern Med.14:299.
Moghadamtousi SZ, Karimian H, Rouhollahi E, Paydar M, Fadaeinasab M, Kadir HA. 2014. Annona muricata leaves induce g1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. J Ethnopharmacol. 156:277-289.
Moghadamtousi, S. Z., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H. M. and Kadir, H. A. 2015a. 'Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities', in Battino, M. (ed.) Int J Mol Sci: Vol. 7, pp. 15625-58.
Moghadamtousi, S. Z., Karimian, H., Rouhollahi, E., Paydar, M., Fadaeinasab, M. and Kadir, H. A. 2015b. 'Annona muricata leaves induce G 1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells', Journal of ethnopharmacology, 156, pp. 277-289.
Monigatti, M., Bussmann, R.W., Weckerle, C.S., 2013. J. Ethnopharmacol. 145, 450–464.
Nakanishi, Y., Chang, F.R., Liaw, C.C., Wu, Y.C., Bastow, K.F., Lee, K.H. 2003. Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line. J. Med. Chem. 46, 3185–3188.
Nawwar M, Ayoub N, Hussein S, Hashim A, El-Sharawy R, Wende K. 2012. Flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata linn. Arch Pharm Res. 35:761-767.
Nugraha AS, Keller PA. 2011. Revealing indigenous Indonesian traditional medicine: anti-infective agents. Nat Prod Com. 6:1953–1966.
Nugraha, A. S., Haritakun, R., Lambert, J. M., Dillon, C. T., Keller, P. A. 2019. Alkaloids from the root of Indonesian Annona muricata L. Natural Product Research, 1–9. doi:10.1080/14786419.2019.1638386.
Nwaehujor, G. A. Olatunji, O. A. Fabiyi and S. A. Akande. 2020. Antioxidant and anti-inflammatory potential, and chemical composition of fractions of ethanol extract of Annona muricata leaf. Ruhuna Journal of Science. 11 (2): 131-142.
Nwokocha CR, Owu DU, Gordon A, Thaxter K, McCalla G, Ozolua RI. 2012. Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive sprague-dawley rats. Pharm. Biol. 50:1436-1441. Int. J Mol Sci. 2015; 16:15657.
Olakunle Sanni, Onyechi Obidoa, James Omale. 2014. Toxicity, anti-lipid peroxidation, invitro and invivo evaluation of antioxidant activity of Annona muricata ethanol stem bark extract. American Journal of Life Sciences. 2(5): 271-277
Oluyege J.O., P.I. Orjiakor, O.E. Badejo. 2019. Phytochemical screening and in vitro antimicrobial properties of Annona muricata extracts against certain human pathogens. Scientific Journals of the Maritime University of Szczecin. 60 (132), 203–209
Ong, H.G., Kim, Y.-D. 2014. Quantitative ethnobotanical study of the medicinal plants used by the Ati Negrito indigenous group in Guimaras Island. Philippines. J. Ethnopharmacol. 157: 228–242.
Padmini, K., Lohita, M., Sumakala, S., Vishnupriya, M., Gowtham Kumar, Y.,
Ramyasudha, E. M. 2014. Synthesis, characterization and antimicrobial evaluation of dihydro-5-substituted-2-thioxopyrimidines. Asian
Journal of Pharmaceutical Analysis and Medicinal Chemistry, 2(2), 63–70.
Ragasa, A.Y., Soriano, G., Torres, G.B., Don, M., Shen, C., 2012. Acetogenins from Annona muricata. Pharmacogn. J. 32, 32–37
Rieser MJ, Fang XP, Anderson JE, Miesbauer LR, Smith DL, McLaughlin JL. 1993. Muricatetrocins a and b and gigantetrocin b: Three new cytotoxic monotetrahydrofuran-ring acetogenins from Annonamuricata. Helv. Chim. Acta; 76:2433-2444.
Roduan, M. R. M., Hamid, R. A., Kqueen, C. Y., & Mohtarrudin, N. 2018. Cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata in vitro. Journal of Herbal Medicine. doi:10.1016/j.hermed.2018.04.004
Ross, I.A., 2010. Medicinal plants of the world, second ed. Chemical
Constituents, Traditional and Modern Medicinal, vol. 1 Humana
Press, Totowa, pp. 133–142.
Safa A. Algeryani, Najwa F. Al Shwihdy, Ruwida M. K. Omar,Nouha El-shinitri, Radwan A. Alnajjar. Review of Biological Properties, Composition and Toxicity of Annonna Muricata. The Scientific Journal of University of Benghazi. 33(1): 5-10.
Samuel, A.J.S.J., Kalusalingam, A., Chellappan, D.K., Gopinath, R., Radhamani, S., Husain, Hj A., Muruganandham, V., Promwichit, P., 2010. Ethnomedical survey of plants used by the Orang Asli in Kampung Bawong, Perak, West Malaysia. J. Ethnobiol. Ethnomed. 6, 1–6.
Sarumaha, Murnihati. 2019. Studi Etnobotani Tanaman Obat Keluarga di Desa Bawolowalani Kecamatan Telukdalam Kabupaten Nias Selatan. Jurnal Education and development. 7(4).
Sasso Sandramara, Priscilla Cristovam Sampaio e Souza, Lidiani Figueiredo Santana, Claudia Andréa Lima Cardoso, Flávio Macedo Alves, Luciane Candeloro Portugal, Bernardo Bacelar de Faria, Anderson Fernandes da Silva, Ana Rita Coimbra Motta-Castro, Luana Silva Soares, Larissa Melo Bandeira, Rita de Cássia Avellaneda Guimarães , Karine de Cássia Freitas. 2019. Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice. Nutrients. 11, 1509; doi:10.3390/nu11071509
Sholikhah Eti Nurwening. 2016. Indonesian medicinal plants as sources of secondary metabolites for pharmaceutical industry. Journal of the Meducal Science. J Med Sci. 48( 4). 226-239.
Ssenyange, C.W., Namulindwa, A., Oyik, B., Ssebuliba, J. 2015.
Plants used to manage type II diabetes mellitus in selected districts
of central Uganda. 15 (2), 496–502
Sun, S., Liu, J., Kadouh, H., Sun, X., & Zhou, K. 2014. Three new anti-proliferative Annonaceous acetogenins with monotetrahydrofuran ring from graviola fruit (Annona muricata). Bioorganic & medicinal chemistry letters. 24(12), 2773-2776.
Tisott, G., Molin, D., Colet, C.D.F. 2013. The use of medicinal plants and herbal medicines for patients in chemotherapy in an oncology center of Ijuı´/RS. O Mundo da Sau´ de 39 (3): 287–298
Vila-Nova, N.S., de Morais, S.M., Falcao, M.J., Alcantara, T.T., Ferreria, P.A., Cavalcanti, E.S., Vieira, I.G., Campello, C.C., Wilson, M., 2013. Different susceptibilities of Leishmania spp. Promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Exp. Parasitol. 133, 334–338.
Wu FE, Gu ZM, Zeng L, Zhao GX, Zhang Y, McLaughlin JL. 1995. Two new cytotoxic monotetrahydrofuran annonaceous acetogenins, annomuricins a and b, from the leaves of Annona muricata. J Nat Prod. 58:830-836.
Wu FE, Zeng L, Gu ZM, Zhao GX, Zhang Y, Schwedler JT et al. New bioactive monotetrahydrofuran annonaceous acetogenins, annomuricin c and muricatocin c, from the leaves of Annona muricata. J Nat Prod. 1995; 58:909-915
Wu FE, Zhao GX, Zeng L, Zhang Y, Schwedler JT, McLaughlin JL. 1995. Additional Bioactive Acetogenins, Annomutacin and (2, 4-trans and cis)-10R-Annonacin-Aones, from the Leaves of Annona muricata. J Nat Prod. 58:1430-1437.
Wu FE, Zeng L, Gu ZM, Zhao GX, Zhang Y, Schwedler JT. 1995. Muricatocins a and b, two new bioactive monotetrahydrofuran annonaceous acetogenins from the leaves of Annona muricata. J Nat Prod.58:902-908.
Wu FE, Zeng L, Gu ZM, Zhao GX, Zhang Y, Schwedler
JT. 1995. New bioactive monotetrahydrofuran annonaceous
acetogenins, annomuricin c and muricatocin c, from the
leaves of Annona muricata. J Nat Prod. 58:909-915
Zeng, L., Ye, Q., Oberlies, N.H., Shi, G., Gu, Z.M., He, K., McLaughlin, J.L. 1996. Recent advances in Annonaceous acetogenins. Nat. Prod. Rep. 13, 275–306.
Zuddin Riva Rainiza dan Abadi Hafizhatul. 2016. Uji Toksisitas Ekstrak Etanol Daun Sirsak (Annona muricata L.) pada Larva Udang (Artemia salina Leach.). Jurnal Dunia Farmasi. 1(1): 30-3.
Adewole, S. and Ojewole, J. 2009. Protective effects of Annona muricata Linn.(Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats'. African journal of traditional, complementary and alternative medicines. 6(1).
Adeyemi D., Komolafe O., Adewole O., Obuotor E., Abiodun A., Adenowo T.
2010. Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata. Folia Morphol. 69(2):92-100.
Adeyemi D., Komolafe O., Adewole S., Obuotor E. 2009. Anti hyperlipidemic activities of Annona muricata (Linn). Internet J Altern Med. 7(1):1-7
Adeyemi DO, Komolafe OA, Adewole OS, Obuotor EM, Adenowo TK. Antihyperglycemic activities of Annona muricata (Linn). Afr. J Tradit Complement Altern Med. 2009; 6:62-69
Adeyemi DO, Komolafe OA, Adewole SO, Obuotor EM, Adenowo TK. 2008. Effects of Annona muricata (Linn) on the morphology of pancreatic islet cells of experimentallyinduced diabetic wistar rats. Internet J Altern Med. 5:2
Agbai E., Mounmbegna P., Njoku C., Nwanegwo C., Awemu G., Iwuji S. 2015. Effect
of Annona muricata seed extract on blood glucose, total and differential white cell count after repeated exposure to clozapine. Res Neurosci. 4(1):10-15.
Agu KC, Okolie PN. 2017. Proximate composition, phytochemical analysis, and in vitro antioxidant potentials of extracts of Annona muricata (Soursop). Food Sci Nutr. 5:1029–1036. https://doi.org/10.1002/fsn3.498 20487177.
Algeryani, Safa A., Najwa F. A, Shwihdy, Ruwida M. K. Omar, Nouha El-shinitri, Radwan A. Alnajjar. 2020. Review of Biological Properties, Composition and Toxicity of Annonna Muricata. The Scientific Journal of University of Benghazi Medical Sciences. 33(1): 5 – 10.
Alonso-Castro, A.J., Villarreal, M.L., Salazar-Olivo, L., GomezSanchez, M., Dominguez, F., Garcia-Carranca, A. 2011. Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and etnobotanical studies. J. Ethnopharmacol. 133, 945–972
Ana V. Coria-Te´ llez, Efigenia Montalvo-Go´ nzalez, Elhadi M. Yahia,
Eva N. Obledo-Va´ zquez. 2016. Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry.
Ani, Novi, Sukenti, Kurniasih, Aryanti, Evy, Rohyani , Immy Suci. 2021. Ethnobotany Study of Medicinal Plants by the Mbojo Tribe Community in Ndano Village at the Madapangga Nature Park, Bima, West Nusa Tenggara. Jurnal Biologi Tropis. 21 (2): 456 – 469.
Arthur, F.K., Woode, E., Terlabi, E., Larbie, C., 2012a. Bilirubin lowering potential of Annona muricata (Linn.) in temporary jaudiced rats. Am. J. Pharmacol. Toxicol. 7, 33–40. Arthur, F.K., Woode, E., Terlabi, E., Larbie, C., 2012b. Evaluation of hepatoprotetctive effect of aqueous extract of Annona muricata (Linn.) leaf against carbon tetrachloride and acetaminopheninduced liver damage. J. Nat. Pharm. 3, 25–30
Aversa, Raffaella and Petrescu, Relly Victoria and Apicella, Antonio and Petrescu, 2016. Florian Ion, One Can Slow Down the Aging Through Antioxidants. American Journal of Engineering and Applied Sciences, Volume 9, Issue 4 (2016), Available at SSRN: https://ssrn.com/abstract=3074497
Badrie N, Schauss AG. Soursop. 2010. (Annona muricata L.): Composition, Nutritional Value, Medicinal Uses, and Toxicology, Bioactive Foods in Promoting Health, Ch. 39:621-641.
Badrie, N., Schauss, A.G., 2009. Soursop (Annona muricata L.): composition, nutritional value, medicinal uses, and toxicology. In: Watson, R.R., Preedy, V.R (eds.), Bioactive Foods in Promoting Health. Oxford, pp. 621–643
Baskar, R., Rajeswari, V. and Kumar, T. S. 2007. In vitro antioxidant studies in leaves of Annona species'. Indian J Exp Biol. 45(5), pp. 480-5.
Bento, E.B., Matias, E.F.F., Brito, F.E., Oliveira, D.R., Coutinho, H.D.M., Costa, J.G.M., Kerntopf, M.R., Menezes, I.R.. 2013.Association between food and drugs: antimicrobial and synergistic activity of Annona muricata L. Int. J. Food Prop. 16 (4), 738–744
Berawi K.N., Shidarti L., Nurdin S.U., Lipoeto N.I., Wahid I. 2017. Comparison Effectiveness of Antidiabetic Activity Extract Herbal Mixture of Soursop Leaves (Annona muricata), Bay Leaves (Syzygium Polyanthum) and Pegagan Leaves (Centella Asiatica). Biomed Pharmacol J. 10(3):1481-1488
Boulogne, I., Germose´ n-Robineau, L., Ozier-Lafontaine, H., Fleury,M., Loranger Merciris, G., 2011. TRAMIL ethnopharmalogical survey in les Saintes (Guadeloupe, French West Indies): a comparative study. J. Ethnopharmacol. 133 (3), 1039–1050.
Bradacs, G., Heilmann, J., Weckerle, C.S., 2011. Medicinal plant use in Vanautu: a comparative ethnobotanical study of three islands. J. Ethnopharmacol. 137, 434–448.
Braguini, W.L., Pires, N.V. and Alves, B.B. 2018. Phytochemical Analysis, Antioxidant Properties and Brine Shrimp Lethality of Unripe Fruits of Solanum viarum. Journal of Young Pharmacists, 10(2).
Bussmann, R.W., Malca, G., Glenn, A., Sharon, D., Nilsen, B., Parris, B., Townesmith, A., 2010. Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies. J. Ethnopharmacol. 132: 101–108.
Champy, P., Gue´ rineau, V., Lapre´ vote, O., 2009. MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata products for human consumption. Molecules 14, 5235–5246.
Chang, F.R., Wu, Y.C., 2001. Novel cytotoxic Annonaceous acetogenins from Annona muricata. J. Nat. Prod. 64, 925–931.
Clarkson, C., Maharaj, V.J., Crouch, N.R., Grace, O.M., Pillay, P., Matsabisa, M. G.,Bhagwandin, N. Smith, P.J. and Folb, P.I. (2004). In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. Journal of Ethnopharmacology, 92(2-3), 177-191.
Coria-Téllez, A. V., Montalvo-Gónzalez, E., Yahia, E. M., & Obledo-Vázquez, E. N. (2018). Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry, 11(5), 662–691.
Daglia, M. 2012. Polyphenols as antimicrobial agents. Current Opinion in Biotechnology, 23(2): 174-181.
De Souza R, Benassi E, da Silva RR, Afonso S, Scarminio IS. Enhanced extraction yields and mobile phase separations by solvent mixtures for the analysis of metabolites in Annona muricata L. Leaves. J Sep Sci. 2009; 32:4176-4185.
De Souza, K., Tchacondo, T., Djikpo Tchibozo, M.A., AbdoulRahaman, S., Anani, K., Koudouvo, K., Batawila, K., Agbonon, A., Simpore, J., De Souza, C., 2011. Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the Central Region of Togo. Pharm. Biol. 49,
1286–1297
Ekor Martins. 2014. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology. 4 (177): 1-10. https://doi.org/10.3389/fphar.2013.00177.
Elekofehinti, O. O., Lawal, A. O., Ejelonu, O. C., Molehin, O. R., & Famusiwa, C. D. 2020. Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies. Journal of Diabetes and Metabolic Disorders. doi:10.1007/s40200-020-00491-7
Elfahmi E, Woerdenbag HJ, Kayser O. 2014. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med 4: 51-73. DOI: DOI: 10.1016/j.hermed.2014.01.002.
Ezirim A, Okachi V, James A, Adebeshi O, Ogunnowo S, Odeghe O. 2013. Induction of apoptosis in myelogenous leukemic k562 cells by ethanolic leaf extract of Annona muricata. Indian J Drug Dis. 2013; 2:142-151
Florence, N.T.; Benoit, M.Z.; Jonas, K.; Alexandra, T.; Desire, D.D.; Pierre, K.; Theophile, D. 2014. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats. J. Ethnopharmacol. 151: 784–790. [CrossRef] [PubMed]
Gajalakshmi S, Vijayalakshmi S And Devi Rajeswar. 2012. Phytochemical And Pharmacological Properties of Annona Muricata: A Review. Intenational journal of Pharmacy and Pharmaceutical science. 4(2).
George, V.C., Kumar, D.R., Rajkumar, V., Suresh, P.K., Ashok, K., 2012. Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. In normal and immortalized human cell lines. Asian Pac. J. Cancer Prev. 13, 699–704.
Hajdu, Z., Hohmann, J., 2012. An ethnopharmacological survey of the traditional medicine utilized in the community of Porvenir, Bajo Paraguay Indian Reservation, Bolivia. J. Ethnopharmacol. 139 (3), 838–857.
Hardoko Y.H., Wijoyo S., Halim Y. 2015. In vitro antidiabetic activity of “green tea” soursop
leaves brew through α-glucosidase inhibition. Int J PharmTech Res. 8(1):30-37.
Hasrat, J. A., De Bruyne, T., DE BACKER, J. P., Vauquelin, G., & Vlietinck, A. J. 1997. Isoquinoline derivatives isolated from the fruitof Annona muricata as 5‐HTergic 5‐HT1A receptor agonists in rats: unexploited antidepressive (lead) products. Journal of pharmacy and pharmacology. 49(11): 1145- 1149
Hosseinzadeh, Saleh, Azizollah Jafarikukhdan, Hosseini , Ahmadreza, Armand Raham. 2015. The Application of Medicinal Plants in Traditional and Modern Medicine: A Review of Thymus vulgaris. International Journal of Clinical Medicine. 6: 635-642.
J.O. Oluyege, P.I. Orjiakor, O.E. Badejo. 2019. Phytochemical screening and in vitro antimicrobial properties of Annona muricata extracts against certain human pathogens. Scientific Journals of the Maritime University of Szczecin. 60 (132), 203–209.
Jadid N, Kurniawan E, Himayani CES, Andriyani, Prasetyowati I, Purwani KI, Muslihatin W, Hidayati D, Tjahjaningrum ITD. 2020. An ethnobotanical study of medicinal plants used by the Tengger tribe in Ngadisari village, Indonesia. PLoS ONE 15(7): e0235886. DOI: 10.1371/journal.pone.0235886.
Jaramillo M, Arango G, Gonzalez M, Robledo S, Velez ID. 2000. Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia.71:183-186.
Jiménez VM, Gruschwitz M, Schweiggert RM, Carle R, Esquivel P. 2014. Identification of phenolic compounds in soursop (Annona muricata) pulp by high-performance liquid chromatography with diode array and electrospray ionization mass spectrometric detection. Food Res Int. 65:42-46.
Justino A.B., Miranda N.C., Franco R.R., Martins M.M., da Silva N.M.. 2008. Espindola
F.S. Annona muricata Linn. leaf as a source of antioxidant compounds with in
vitro antidiabetic and inhibitory potential against α-amylase, α-glucosidase, lipase,
non-enzymatic glycation and lipid peroxidation. Biomed Pharmacother. 100:83-92[CrossRef] [PubMed].
Kim GS, Zeng L, Alali F, Rogers LL, Wu FE, McLaughlin JL. 1998. Two new mono-tetrahydrofuran ring acetogenins, annomuricin e and muricapentocin, from the
leaves of Annona muricata. J Nat Prod.; 61:432-436.
Kim, G.-T., Cho, K.-H., Sharma, A., Devi, S., & Park, T.-S. 2021. Annona muricata leaf extract attenuates hepatic lipogenesis and adipogenesis. Food & Function, 12(10), 4621 4629. doi:10.1039/d1fo00509j
Kim GS, Zeng L, Alali F, Rogers LL, Wu FE, Sastrodihardjo S. 1998. Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata in honour of professor gh neil towers 75th birthday. Phytochemistry. 49:565-571.
Kuete, V., Mbaveng, A.T., Nono, E.C., Simo, C.C., Zeino, M., Nkengfack, A. E.and Efferth, T. 2016. Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells. Phytomedicine, 23(8): 856-863.
Langenberger, G., PriggeKonrad, V., Martin, K., Belonias, B. 2009. Ethnobotanical knowledge of Philippine lowland farmers and its application in agroforestry. Agrofor. Syst. 76: 173–1994
Leon-Fernandez AE, Sayago-Ayerdi SG, Velazquez-Estrada RM, Zepeda-Vallejo LG, Yahia E, Montalvo-Gonzalez E. 2017. In-vitro antioxidant capacity of crude extracts and acetogenin fraction of soursop fruit pulp. Pharmaceutica Analytica Acta. 8(6): 550 – 556. DOI: 10.4172/2153- 2435.1000550
Liaw, C.C., Chang, F.R., Lin, C.Y., Chou, C.J., Chiu, H., Wu, M.J., 2002. New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. J. Nat. Prod. 65: 470–476.
Melot, A., Fal, D., Gleye, C., Champy, P. 2009. Apolar annonaceous acetogenins from the fruit pulp of Annona muricata. Molecules. 14:4387–4395
Mishra S, Ahmad S, Kumar N, Sharma BK. 2013. Annona muricata (the cancer killer): A review. Glob. J Pharm Res. 2:1613-1618.
Moghadamtousi Soheil Zorofchian , Fadaeinasab Mehran , Nikzad Sonia, Mohan Gokula , Ali Hapipah Mohd and Abdul Kadir Habsah. 2015. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. International journal of molecular science. 16:15625-15658.
Moghadamtousi SZ, Kadir HA, Paydar M, Rouhollahi E, Karimian H. 2014. Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB. BMC Complement Altern Med.14:299.
Moghadamtousi SZ, Karimian H, Rouhollahi E, Paydar M, Fadaeinasab M, Kadir HA. 2014. Annona muricata leaves induce g1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. J Ethnopharmacol. 156:277-289.
Moghadamtousi, S. Z., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H. M. and Kadir, H. A. 2015a. 'Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities', in Battino, M. (ed.) Int J Mol Sci: Vol. 7, pp. 15625-58.
Moghadamtousi, S. Z., Karimian, H., Rouhollahi, E., Paydar, M., Fadaeinasab, M. and Kadir, H. A. 2015b. 'Annona muricata leaves induce G 1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells', Journal of ethnopharmacology, 156, pp. 277-289.
Monigatti, M., Bussmann, R.W., Weckerle, C.S., 2013. J. Ethnopharmacol. 145, 450–464.
Nakanishi, Y., Chang, F.R., Liaw, C.C., Wu, Y.C., Bastow, K.F., Lee, K.H. 2003. Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line. J. Med. Chem. 46, 3185–3188.
Nawwar M, Ayoub N, Hussein S, Hashim A, El-Sharawy R, Wende K. 2012. Flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata linn. Arch Pharm Res. 35:761-767.
Nugraha AS, Keller PA. 2011. Revealing indigenous Indonesian traditional medicine: anti-infective agents. Nat Prod Com. 6:1953–1966.
Nugraha, A. S., Haritakun, R., Lambert, J. M., Dillon, C. T., Keller, P. A. 2019. Alkaloids from the root of Indonesian Annona muricata L. Natural Product Research, 1–9. doi:10.1080/14786419.2019.1638386.
Nwaehujor, G. A. Olatunji, O. A. Fabiyi and S. A. Akande. 2020. Antioxidant and anti-inflammatory potential, and chemical composition of fractions of ethanol extract of Annona muricata leaf. Ruhuna Journal of Science. 11 (2): 131-142.
Nwokocha CR, Owu DU, Gordon A, Thaxter K, McCalla G, Ozolua RI. 2012. Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive sprague-dawley rats. Pharm. Biol. 50:1436-1441. Int. J Mol Sci. 2015; 16:15657.
Olakunle Sanni, Onyechi Obidoa, James Omale. 2014. Toxicity, anti-lipid peroxidation, invitro and invivo evaluation of antioxidant activity of Annona muricata ethanol stem bark extract. American Journal of Life Sciences. 2(5): 271-277
Oluyege J.O., P.I. Orjiakor, O.E. Badejo. 2019. Phytochemical screening and in vitro antimicrobial properties of Annona muricata extracts against certain human pathogens. Scientific Journals of the Maritime University of Szczecin. 60 (132), 203–209
Ong, H.G., Kim, Y.-D. 2014. Quantitative ethnobotanical study of the medicinal plants used by the Ati Negrito indigenous group in Guimaras Island. Philippines. J. Ethnopharmacol. 157: 228–242.
Padmini, K., Lohita, M., Sumakala, S., Vishnupriya, M., Gowtham Kumar, Y.,
Ramyasudha, E. M. 2014. Synthesis, characterization and antimicrobial evaluation of dihydro-5-substituted-2-thioxopyrimidines. Asian
Journal of Pharmaceutical Analysis and Medicinal Chemistry, 2(2), 63–70.
Ragasa, A.Y., Soriano, G., Torres, G.B., Don, M., Shen, C., 2012. Acetogenins from Annona muricata. Pharmacogn. J. 32, 32–37
Rieser MJ, Fang XP, Anderson JE, Miesbauer LR, Smith DL, McLaughlin JL. 1993. Muricatetrocins a and b and gigantetrocin b: Three new cytotoxic monotetrahydrofuran-ring acetogenins from Annonamuricata. Helv. Chim. Acta; 76:2433-2444.
Roduan, M. R. M., Hamid, R. A., Kqueen, C. Y., & Mohtarrudin, N. 2018. Cytotoxicity, antitumor-promoting and antioxidant activities of Annona muricata in vitro. Journal of Herbal Medicine. doi:10.1016/j.hermed.2018.04.004
Ross, I.A., 2010. Medicinal plants of the world, second ed. Chemical
Constituents, Traditional and Modern Medicinal, vol. 1 Humana
Press, Totowa, pp. 133–142.
Safa A. Algeryani, Najwa F. Al Shwihdy, Ruwida M. K. Omar,Nouha El-shinitri, Radwan A. Alnajjar. Review of Biological Properties, Composition and Toxicity of Annonna Muricata. The Scientific Journal of University of Benghazi. 33(1): 5-10.
Samuel, A.J.S.J., Kalusalingam, A., Chellappan, D.K., Gopinath, R., Radhamani, S., Husain, Hj A., Muruganandham, V., Promwichit, P., 2010. Ethnomedical survey of plants used by the Orang Asli in Kampung Bawong, Perak, West Malaysia. J. Ethnobiol. Ethnomed. 6, 1–6.
Sarumaha, Murnihati. 2019. Studi Etnobotani Tanaman Obat Keluarga di Desa Bawolowalani Kecamatan Telukdalam Kabupaten Nias Selatan. Jurnal Education and development. 7(4).
Sasso Sandramara, Priscilla Cristovam Sampaio e Souza, Lidiani Figueiredo Santana, Claudia Andréa Lima Cardoso, Flávio Macedo Alves, Luciane Candeloro Portugal, Bernardo Bacelar de Faria, Anderson Fernandes da Silva, Ana Rita Coimbra Motta-Castro, Luana Silva Soares, Larissa Melo Bandeira, Rita de Cássia Avellaneda Guimarães , Karine de Cássia Freitas. 2019. Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice. Nutrients. 11, 1509; doi:10.3390/nu11071509
Sholikhah Eti Nurwening. 2016. Indonesian medicinal plants as sources of secondary metabolites for pharmaceutical industry. Journal of the Meducal Science. J Med Sci. 48( 4). 226-239.
Ssenyange, C.W., Namulindwa, A., Oyik, B., Ssebuliba, J. 2015.
Plants used to manage type II diabetes mellitus in selected districts
of central Uganda. 15 (2), 496–502
Sun, S., Liu, J., Kadouh, H., Sun, X., & Zhou, K. 2014. Three new anti-proliferative Annonaceous acetogenins with monotetrahydrofuran ring from graviola fruit (Annona muricata). Bioorganic & medicinal chemistry letters. 24(12), 2773-2776.
Tisott, G., Molin, D., Colet, C.D.F. 2013. The use of medicinal plants and herbal medicines for patients in chemotherapy in an oncology center of Ijuı´/RS. O Mundo da Sau´ de 39 (3): 287–298
Vila-Nova, N.S., de Morais, S.M., Falcao, M.J., Alcantara, T.T., Ferreria, P.A., Cavalcanti, E.S., Vieira, I.G., Campello, C.C., Wilson, M., 2013. Different susceptibilities of Leishmania spp. Promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Exp. Parasitol. 133, 334–338.
Wu FE, Gu ZM, Zeng L, Zhao GX, Zhang Y, McLaughlin JL. 1995. Two new cytotoxic monotetrahydrofuran annonaceous acetogenins, annomuricins a and b, from the leaves of Annona muricata. J Nat Prod. 58:830-836.
Wu FE, Zeng L, Gu ZM, Zhao GX, Zhang Y, Schwedler JT et al. New bioactive monotetrahydrofuran annonaceous acetogenins, annomuricin c and muricatocin c, from the leaves of Annona muricata. J Nat Prod. 1995; 58:909-915
Wu FE, Zhao GX, Zeng L, Zhang Y, Schwedler JT, McLaughlin JL. 1995. Additional Bioactive Acetogenins, Annomutacin and (2, 4-trans and cis)-10R-Annonacin-Aones, from the Leaves of Annona muricata. J Nat Prod. 58:1430-1437.
Wu FE, Zeng L, Gu ZM, Zhao GX, Zhang Y, Schwedler JT. 1995. Muricatocins a and b, two new bioactive monotetrahydrofuran annonaceous acetogenins from the leaves of Annona muricata. J Nat Prod.58:902-908.
Wu FE, Zeng L, Gu ZM, Zhao GX, Zhang Y, Schwedler
JT. 1995. New bioactive monotetrahydrofuran annonaceous
acetogenins, annomuricin c and muricatocin c, from the
leaves of Annona muricata. J Nat Prod. 58:909-915
Zeng, L., Ye, Q., Oberlies, N.H., Shi, G., Gu, Z.M., He, K., McLaughlin, J.L. 1996. Recent advances in Annonaceous acetogenins. Nat. Prod. Rep. 13, 275–306.
Zuddin Riva Rainiza dan Abadi Hafizhatul. 2016. Uji Toksisitas Ekstrak Etanol Daun Sirsak (Annona muricata L.) pada Larva Udang (Artemia salina Leach.). Jurnal Dunia Farmasi. 1(1): 30-3.
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2022-11-05
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