Anemia Megaloblastik: Sebuah Tinjauan Pustaka
Abstract
Anemia megaloblastik merupakan anemia yang ditandai dengan membesarnya eritroblast di sumsum tulang sehingga menganggu pematangan inti sel dan pembelahan sel eritrosit. Kelainan utamanya disebabakan karena defisiensi vitamin B-12 dan asam folat sehingga sintesis DNA terganggu. Diagnosis anemia megaloblastik dilakukan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pengobatannya dilakukan berdasarkan etiologi yang mendasari. Semakin cepat didiagnosis, prognosisnya akan semakin baik. Penting untuk mengenali, mencegah, dan mengobati anemia megaloblastik.
References
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19. Castellanos-Sinco HB, Ramos-Peñafiel CO, Santoyo-Sánchez A, Collazo-Jaloma J, Martínez-Murillo C, Montaño-Figueroa E, et al. Megaloblastic anaemia: Folic acid and vitamin B12 metabolism. Rev Médica Del Hosp Gen México. 2015;78(3):135–43.
2. Oehadian A. Pendekatan Klinis dan Diagnosis Anemia. CDK. 2012;39(6):407–12.
3. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. 9th ed. Philadelphia: Elsevier; 2013. 1689–1699 p.
4. Nugroho MR, Sartika RAD. Asupan Vitamin B12 Terhadap Anemia Megaloblastik Pada Vegetarian Di Vihara Meitriya Khirti Palembang. J Kesehat Komunitas. 2018;4(2):40–5.
5. Schick P. Megaloblastic anemia [Internet]. Medscape. 2019. Available from: https://emedicine.medscape.com/article/204066-overview
6. Pandya HP, Patel A. Clinical profile and response in patients with megaloblastic anemia. Int J Med Sci Public Heal. 2016;5(2):304.
7. Srikanth S. Megaloblastic anemia - A clinical spectrum and a hematological profile: The day-to-day public health problem. Med J Dr DY Patil Univ. 2016;9(3):307–10.
8. Socha DS, DeSouza SI, Flagg A, Sekeres M, Rogers HJ. Severe megaloblastic anemia: Vitamin deficiency and other causes. Cleve Clin J Med. 2020;87(3):153–64.
9. Green R. Review Article Vitamin B 12 de fi ciency from the perspective of a practicing hematologist. Blood. 2017;129(19):2603–12.
10. Rodriguez NM, Karen S. Pernicious Anemia Pathophysiology. StatPearl Publ LLC. 2020;
11. Merrell BJ, John P. McMurry. Folic acid. StatPearl Publ LLC [Internet]. 2020;53(2):61–8. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554487/
12. Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med Clin North Am [Internet]. 2017;101(2):297–317. Available from: http://dx.doi.org/10.1016/j.mcna.2016.09.013
13. Hoffbrand A V., Moss PAH. Essential Haematology. 6th ed. West Sussex: Wiley Blackwell; 2011.
14. Iqbal MA, Niroula R, Singh P, Khan M. Tongue disorders due to megaloblastic anaemia and its management: A case report. Updat Dent Coll J. 2021;11(1):26–8.
15. Bawaskar HS, Bawaskar PH, Bawaskar PH, Parekh PB. Tropical megaloblastic anaemia. Lancet [Internet]. 2019;393(10187):2261. Available from: http://dx.doi.org/10.1016/S0140-6736(19)31123-7
16. Hariz A, Bhattacharya PT. Megaloblastic Anemia Pathophysiology Histopathology. StatPearl Publ LLC [Internet]. 2021;4–7. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537254/
17. Batool S, Iqbal R. Macrocytic anemia: A review. J Entomol Zool Stud. 2016;4(5):544–7.
18. Obeagu EI, Babar Q, Obeagu GU. Megaloblastic Anaemia -A Review. Int J Curr Res inMedical Sci [Internet]. 2021;7(5):17–24. Available from: https://www.researchgate.net/publication/353609332_Megaloblastic_Anaemia_-A_Review
19. Castellanos-Sinco HB, Ramos-Peñafiel CO, Santoyo-Sánchez A, Collazo-Jaloma J, Martínez-Murillo C, Montaño-Figueroa E, et al. Megaloblastic anaemia: Folic acid and vitamin B12 metabolism. Rev Médica Del Hosp Gen México. 2015;78(3):135–43.
Published
2022-11-05
Section
Articles
