Patterns of Use and Rationality of Drug Therapy in Patients with Congestive Heart Failure (CHF)
DOI:
https://doi.org/10.30812/biocity.v3i2.5470Keywords:
CHF, Drug use evaluation, Hospitalization, Rational therapyAbstract
Congestive Heart Failure (CHF) is a cardiovascular disease with high prevalence and significant morbidity and mortality rates. Rational pharmacotherapy management is crucial to reducing hospitalization rates and improving patient quality of life. This study aims to evaluate medication use among hospitalized CHF patients using the parameters of correct diagnosis, correct indication, correct medication, and correct dosage. This study design is descriptive, observational, with a retrospective approach, using medical records of CHF patients treated at Dr. Soeselo Regional Hospital, Tegal Regency, during July–December 2024. A sample of 79 patients was analyzed. The results showed that the most commonly used drug classes were loop diuretics (furosemide), beta-blockers (bisoprolol, carvedilol), aldosterone antagonists (spironolactone), ARBs (candesartan), and ACE-I (ramipril, captopril). The majority of patients received therapy at doses consistent with standard CHF therapy, and the longest hospitalization was 7 days. The evaluation showed that all patients received therapy that met the four indicators of rational drug use (100% correct diagnosis, indication, drug, and correct dosage). Based on the study results, it can be concluded that the use of CHF drugs in hospitalized patients at Dr. Soeselo Regional Hospital has been implemented rationally and in accordance with national and international therapy guidelines.
References
Anonim. (2023). Profil RSUD Dokter Soeselo Tahun 2023. RSUD Soeselo Kabupaten Tegal.
Aritonang, Anggraini, Y., & Leniwita, H. (2020). Buku I : Modul keperawatan medikal bedah I. In Universitas Kristen Indonesia Institutional Repository.
Deniyati, D. (2023). Profile of Treatment for Patients with Congestive Heart Failure: Profil Pengobatan Pasien dengan Penyakit Congestive Heart Failure. Journal of Environmental and Safety Engineering, 2(2), 111–116.
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., Fang, J. C., Fedson, S. E., Fonarow, G. C., Hayek, S. S., Hernandez, A. F., Khazanie, P., Kittleson, M. M., Lee, C. S., Link, M. S., … Yancy, C. W. (2022). 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology, 79(17), e263–e421. https://doi.org/10.1016/j.jacc.2021.12.012
Kemenkes RI. (2021). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Gagal Jantung. Keputusan Menteri Kesehatan Republik Indonesia Nomor Hk.01.07/Menkes/4801/2021, 31–39.
Kementerian Kesehatan RI. (2011). Modul Penggunaan Obat Rasional kemenkes RI. 1–180.
Kementerian Kesehatan RI. (2024). Survei Kesehatan Indonesia 2023 dalam Angka. Kementerian Kesehatan Republik Indonesia, Badan Kebijakan Pembangunan Kesehatan.
Lolita, L., & Istiani, A. (2019). Evaluasi kerasionalan dan kuantitas penggunaan antihipertensi pada pasien gagal jantung di instalasi rawat inap rumah sakit PKU Muhammadiyah Gamping Yogyakarta. Jurnal Ilmiah Farmasi, 15(1), 37–50. https://doi.org/10.20885/jif.vol15.iss1.art5
McDonagh, T. A., Metra, M., Adamo, M., Baumbach, A., Böhm, M., Burri, H., Čelutkiene, J., Chioncel, O., Cleland, J. G. F., Coats, A. J. S., Crespo-Leiro, M. G., Farmakis, D., Gardner, R. S., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., Lainscak, M., … Koskinas, K. C. (2021). 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. In European Heart Journal (Vol. 42, Issue 36). https://doi.org/10.1093/eurheartj/ehab368
Metra, M., & Teerlink, J. R. (2017). Heart failure. The Lancet, 390(10106), 1981–1995. https://doi.org/10.1016/S0140-6736(17)31071-1
Nopitasari, B. L., Nurbaety, B., & Zuhroh, H. (2020). Evaluasi Penggunaan Obat Antihipertensi pada Pasien Gagal Jantung Rawat Jalan di Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 1(2), 66. https://doi.org/10.31764/lf.v1i2.2542
Nurazizah, Y., L, A. D., Agung, B., M, R., & O, I. (2022). Gambaran pemberian ACEI atau ARB pada gagal jantung. Homeostatis, 5(2), 311–322.
Nurhamsyah, D., Trisyani, Y., Nuraeni, A., & Maziyya, N. (2021). Severity Level and Quality of Life of Post-Acute Coronary Syndrome Patients. Jurnal Keperawatan Padjadjaran, 9(2), 118–123. https://doi.org/10.24198/jkp.v9i2.1661
Nurkhalis, & Adista, R. J. (2020). Manifestasi Klinis dan Tatalaksana Gagal Jantung. Jurnal Kedokteran Nanggroe Medika, 3(3), 36–46. https://doi.org/DOI:10.35324/JKNAMED.V3I3.106
Ostergren, J. B. (2006). Angiotensin receptor blockade with candesartan in heart failure: findings from the Candesartan in Heart failure--assessment of reduction in mortality and morbidity (CHARM) programme. Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension, 24(1), S3-7. https://doi.org/10.1097/01.hjh.0000220400.08128.fa
PERKI. (2020). Pedoman Tatalaksana Gagal Jantung 2020. 2nd ed. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia 2020, 6(11), 951–952.
PERKI. (2023). Pedoman Tatalaksana Gagal Jantung. In Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (Vol. 3).
Prahasti, S. D., & Fauzi, L. (2021). Risiko Kematian Pasien Gagal Jantung Kongestif (GJK). Indonesian Journal of Public Health and Nutrition, 1(3), 388–395.
Rukminingsih, F. (2020). Pengukuran Tekanan Darah Pada Pasien Gagal Jantung Kongestif Di Instalasi Rawat Inap Rumah Sakit St . Blood Pressure Measurement of Inpatients Congestive Heart Failure Patients in St . Elisabeth Hospital Semarang. Jurnal Riset Kefarmasian Indonesia, 2(1), 10–16.
Sahputri, S. E. B., Irawati, A. D., & Azzahra, T. D. (2024). Efektifitas Antihipertensi Pada Pasien Rawat Inap Gagal Jantung Di Rsu Dharma Husada Kabupaten Banyuwangi. Pengembangan Ilmu Dan Praktik Kesehatan, 3(1), 1–8. https://doi.org/10.56586/pipk.v3i1.332
Saida, S., Haryati, H., & Rangki, L. (2020). Kualitas Hidup Penderita Gagal Jantung Kongestif Berdasarkan Derajat Kemampuan Fisik dan Durasi Penyakit. Faletehan Health Journal, 7(02), 70–76. https://doi.org/10.33746/fhj.v7i02.134
Sherly, U., Sjaaf, F., & Puspita, D. (2022). Profil Pasien Gagal Jantung pada Usia Lanjut di Rsup Dr. M. Djamil Padang Tahun 2018-2020. Scientific Journal, 1(3), 165–174. https://doi.org/10.56260/sciena.v1i3.39
Siswanto, B. B., Prameswari, H. S., Padjadjaran, U., Irnizarifka, I., Suciadi, L. P., & Hospitals, S. (2023). Farmakoterapi pada Gagal Jantung Farmakoterapi pada Gagal Jantung Kelompok Kerja Gagal Jantung dan (Issue April). PT. Scifintech Andrew Wijaya.
Tumundo, D., Wiyono, W., & Jayanti, M. (2021). Tingkat Kepatuhan Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Di Puskesmas Kema Kabupaten Minahasa Utara. Pharmacon, 10(4), 1–8.
Wahyuni, K. S. P. D., Hesturini, R. J., Hariyani, & Nabila, S. (2023). Pola Penggunaan Obat pada Pasien Jantung Koroner (ICD 125.1) Rawat Inap di RSUD dr Iskak Tulungagung. Jurnal Pharma Bhakta, 3(2), 31–39.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Adelya Putri Angkasa, Prihastini Setyo Wulandari, Osie Listina

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Adelya Putri Angkasa











