Biocity Journal of Pharmacy Bioscience and Clinical Community

Analisis Ketepatan Penggunaan Antibiotik Profilaksis Pada Pasien Bedah Sesar (Sectio Caesarea)

Anggi Monica, Muh. Wisda Praja Ramdhany, Made Sandhi Pratama Putra — Tue, 30 Apr 2024 22:33:43 +0800

Bedah sesar (sectio caesarea) merupakan persalinan dengan cara pembedahan melalui sayatan pada perut dan rahim. Bedah sesar menjadi metode persalinan yang dapat menimbulkan resiko pasca operasi yaitu Infeksi Luka Operasi (ILO) sehingga diperlukan pemberian antibiotik profilaksis. Antibiotik profilaksis merupakan antibiotik yang digunakan mencegah terjadinya infeksi komplikasi akibat operasi dan diberikan sebelum, saat dan setelah operasi. Pemilihan antibiotik sangat diperhatikan karena penggunaan antibiotik yang tidak tepat dapat menimbulkan resistensi. Tujuan penelitian ini adalah untuk menganalisis profil penggunaan dan mengevaluasi rasionalitas antibiotik profilaksis pada bedah sesar di RSAD Wira Bhakti. Metode pada penelitian ini adalah deskriptif non eksperimental dengan pengumpulan data secara retrospektif berupa rekam medik pasien bedah sesar periode Juli 2022 – Desember 2022. Hasil penelitian yang didapatkan dari 68 rekam medik adalah seftriakson (70,6%), sefotaksim (25%), dan sefoperazon (4,4%). Berdasarkan hasil rasionalitas dengan metode Gyssens, seluruh penggunaan antibiotik profilaksis masuk dalam kategori IVA(alternatif lebih efektif) dan IVD (spektrum alternatif lebih sempit).

Hubungan Kejadian Gastritis Dengan Riwayat Penggunaan Obat Anti Inflamasi Non Steroid (OAINS) Pada Pasien Yang Melakukan Pemeriksaan Endoskopi

Kintan Nandini Nirmala Putri, Fitry Apriliany, Muh. Wisda Praja — Tue, 30 Apr 2024 00:00:00 +0800

Gastritis is defined as inflammation of the gastric mucosa, and one of its causes is the use of medications, specifically Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). The purpose of this research is to examine the relationship between gastritis incidence and the history of NSAID use. The research method employed is an analytical observational study using a Retrospective Cohort design, involving data collection from patients. Data were obtained through interviews with patients and their families, as well as the review of patient medical records during the period of February - May 2023. The statistical test used in this study is the Pearson correlation test. The study mainly included patients aged 36-55 years (46.43%), with 49 respondents being female (58.33%). The results obtained indicate that there is no significant relationship between gastritis incidence and history of NSAID use, with a p-value > 0.05 and an r-value < 1, indicating a weak level of relationship. The conclusion drawn from this research is that the relationship between gastritis incidence and history of NSAID use is weak.

Profil Fitokimia Dan Aktivitas Antibakteri Bunga Kekara Laut (Canavalia rosea) Menggunakan Metode Difusi Cakram

Irman Idrus, Efa Kelya Nasrun, Muhammad Eka Putra Ramandha — Tue, 30 Apr 2024 22:29:30 +0800

Bacterial infection is one of the leading causes of chronic infections and ongoing risks of mortality that continuously threaten public health globally. Improper use of antibiotics can lead to pathogenic bacteria developing resistance to antibiotics and cause dangerous side effects. Therefore, it is important to search for alternative antibiotic sources derived from natural materials. One type of plant that has the potential as an antibacterial agent is Canavalia rosea. This research aims to qualitatively assess the phytochemical content using tube methods and to evaluate the antibacterial activity of the ethyl acetate fraction of Canavalia rosea extract using the disc diffusion method. Extraction of jarak pagar leaves was carried out by maceration method using 96% ethanol, then fractionation was done using ethyl acetate. Phytochemical analysis results showed the presence of alkaloid, saponin, flavonoid, polyphenol, and tannin compounds in the jarak pagar leaf extract. The antibacterial activity of the ethyl acetate fraction of the extract showed significant inhibition zones against the growth of S. aureus bacteria. At a concentration of 9 mg/mL, the inhibition zone reached 20.31 ± 0.27 mm, falling into the moderate to strong category, while at a concentration of 1.5 mg/mL, the inhibition zone reached 5.13 ± 0.32 mm, indicating lower inhibitory effects. Statistical analysis showed that the ethyl acetate fraction of Canavalia rosea extract has significant antibacterial activity, with each concentration having different effects in inhibiting the growth of S. aureus.

Pengaruh Reminding melalui Whatsapp Terhadap Kepatuhan Minum Obat pada Pasien Tuberkulosis Paru

Yovi Agus Saputra, Fitry Apriliany, Muh. Wisda Praja Ramdhany — Tue, 30 Apr 2024 22:05:38 +0800

Pulmonary Tuberculosis is an infectious disease caused by the bacterium Mycobacterium Tuberculosis, which enters the body through inhaled air and spreads in the lungs. In 2021, Mataram City detected a total of 739 TB cases. Many TB patients still exhibit low adherence to taking their medication. The aim of this research is to investigate the influence of reminding through WhatsApp on medication adherence in pulmonary tuberculosis patients and to observe the improvement in the level of medication adherence in these patients. The method used is an analytical observational study with a quasi-experimental design, employing a prospective pre-test and post-test approach. Data is collected from outpatient patients, and medication reminders are sent to the patients. The research results indicate a significant improvement in medication adherence among pulmonary TB patients, with a significant value from the Wilcoxon test (p = 0.000, <0.05). The conclusion drawn from this study is that there is an influence of reminding through WhatsApp on medication adherence in pulmonary tuberculosis patients at the Regional General Hospital of Mataram City.

Analisis Hubungan Karakteristik Dengan Tingkat Pengetahuan Keluarga Pasien Tentang Beyond Use Date (BUD) Obat Sirup Kering

Nur Azizah Atmi, Muh. Wisda Praja Rhamdany, Made Sandi Pratama Putra — Tue, 30 Apr 2024 22:11:18 +0800

Abstract: Almost every household in Indonesia keeps a stock of medicines. However, the public's knowledge about medicine storage remains low, one of which is the term "Beyond Use Date" (BUD). The term BUD in medicine storage is crucial to understand because it relates to the stability and quality of the medicine. If medicine storage is not proper, it can lead to irrational drug usage. The purpose of this study is to determine the relationship between characteristics and the level of knowledge among family members of patients regarding the BUD of dry syrup medicines at the City of Mataram Regional General Hospital (RSUD). This study utilizes a cross-sectional design, employing a validated questionnaire (with reliability ranging from 0.411 to 0.780). The participants in this study are 60 parents or guardians of patients who are prescribed dry syrup medicines. The level of knowledge among the parents or guardians about the BUD of dry syrup medicines is predominantly categorized as good, with 56 individuals (93.3%). The results of bivariate analysis using chi-square indicate that the characteristic with a relationship to the level of knowledge about the BUD of dry syrup medicines is the level of education (p=0.007). Additionally, the domain of supplementary information sources about the BUD of dry syrup medicines is associated with the respondents' knowledge level (p=0.000). In conclusion, this research finds that only the characteristic of education level is correlated with the level of knowledge among parents or guardians about the BUD of dry syrup medicines.

Abstrak: Hampir semua rumah tangga di Indonesia melakukan penyimpan obat. Tetapi pengetahuan masyarakat dalam penyimpanan obat masih rendah, salah satunya adalah istilah Beyond Use Date (BUD). Istilah BUD dalam penyimpanan obat sangat penting untuk diketahui karena BUD berkaitan dengan kestabilan dan mutu obat, jika penyimpanan obat tidak tepat maka dapat mengakibatkan penggunaan obat yang tidak rasional. Tujuan penelitian ini adalah mengetahui hubungan karakteristik dengan tingkat pengetahuan keluarga pasien tentang BUD obat sirup kering di RSUD Kota Mataram. Penelitian ini menggunakan desain cross sectional, dengan instrumen kuesioner yang telah valid (0,411-0,780) dan reliablel (>0,06). Responden yang terlibat pada penelitian ini adalah 60 orang tua atau wali pasien yang mendapatkan obat sirup kering. Tingkat pengetahuan orang tua atau wali pasien tentang BUD obat sirup kering didominasi oleh kategori baik sebanyak 56 orang (93,3%). Hasil analisis bivariat mengunakan chi square, pada karakteristik yang memiliki hubungan dengan tingkat pengetahuan tentang BUD obat sirup kering adalah tingkat pendidikan (p=0,007). Selain itu domain sumber informasi penunjang BUD obat sirup kering memiliki hubungan dengan tingkat pengetahuan responden tentang BUD obat sirup kering (p=0,000). Kesimpulan pada penelitian ini adalah hanya karakteristik tingkat pendidikan yang memiliki hubungan dengan tingkat pengetahuan orang tua atau wali pasien tentan BUD obat sirup kering.