Biocity Journal of Pharmacy Bioscience and Clinical Community

Evaluation of the Level of Medication Adherence of Antiepileptic Drugs (AEDs) on Cognitive Function of Children

Rizki Putri Ayu Dwi Anida — 2024-10-29

Epilepsy is a chronic brain disorder with various causes characterized by recurrent attacks. Epilepsy can affect all ages, including children, which affects around 40%-50%. Epilepsy can have an impact on memory disorders, either caused by symptoms of epilepsy itself, antiepileptic drugs (AEDs), psychosocial factors, or comorbidities. Patients with epilepsy are generally advised to consume AEDs for more than 3 months. This antiepileptic treatment takes a long time, so it is very susceptible to causing patient non-compliance in taking AEDs. Therefore, this study aims to determine the level of compliance of pediatric epilepsy patients and whether there is a relationship between compliance and the cognitive function of pediatric patients. In this study, 54 respondents were used from the Mataram City Hospital polyclinic. Compliance was measured using the Morisky Medication Adherence Scale 8 item (MMAS-8) questionnaire and cognitive function measure using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina). The result based on the MMAS-8 shows that 7.4% of respondents had high compliance, 61.1% had moderate compliance, and 31.5% had low compliance. Data analysis used the Chi-Square test with α = 0.01 and obtained a significance value (p-value = 0.329). Based on these results, it can be concluded that the level of compliance is moderate, and there is no relationship between compliance and cognitive function.

Factors that Influence Pregnant Women’s Knowledge about Neonatal Asphyxia

Hernah Riana — 2024-10-31

Asfiksia neonatorum merupakan salah satu penyebab kurangnya aliran darah atau pertukaran gas ke atau dari janin pada periode segera sebelum, selama atau setelah proses kelahiran. Menurut data World Health Organization (WHO), 28 milyar bayi meninggal setelah 28 hari pertama karena masa itu merupakan masa adaptasi yang dialami oleh bayi untuk menentukan apakah dapat bertahan hidup atau tidak. Salah satu penyebab utamanya adalah asfiksia yang mengakibatkan 11% kematian bayi. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi pengetahuan ibu hamil tentang asfiksia neonatorum berdasarkan umur, paritas dan pendidikan Ibu. Penelitian ini adalah survey analitik dengan pendekatan cross-sectional dan dilaksanakan di wilayah kerja Puskesmas Kolakaasi. Sampel penelitian yang digunakan sebanyak 75 responden dengan instrumen kuesioner. Hasil penelitian menunjukkan bahwa hasil uji statistik dengan uji chi-square, probabilitas lebih kecil α (p < α) (0.001<0.05). Hasil ini secara statistik menunjukkan adanya hubungan yang signifikan antara umur, paritas dan pendidikan Ibu terhadap pengetahuan tentang asfiksia neonatorum. Oleh karena itu dapat disimpulkan bahwa umur, paritas, dan pendidikan berpengaruh terhadap pengetahuan Ibu hamil tentang asfiksia neonatorum.

Antibacterial Activity of Ethanol Extract of Marigold Flower (Tagetes erecta Linn.) against Staphylococcus aureus and Escherichia coli Bacteria

Unggu Putri Six Marsah — 2024-10-31

Gemitir flowers (Tagetes erecta Linn.) contain secondary metabolite compounds such as flavonoids, phenolics, saponins and carotenoids which have the potential as antibacterials that can be used in treating infections caused by pathogenic bacteria Staphylococcus aureus and Escherichia coli. The purpose of this study was to determine the effective concentration of etanol extract of gemitir flowers and the comparison of antibiotic inhibition with etanol extract of gemitir flowers in inhibiting the growth of S. aureus and E. coli bacteria. This study is an experimental study and was analyzed using the One Way ANOVA statistical test. The results showed that gemitir flower extract positively contained secondary metabolites in the form of flavonoids, phenolics and saponins. The antibacterial activity test of etanol extract of gemitir flowers can inhibit S. aureus and E. coli at concentrations of 85%, 90%, 95% and 100% with the diameter of the inhibition zone obtained of 17-31.6 mm which is included in the strong-very strong category. Based on the description above, it can be concluded that the etanol extract of gemitir flowers has the potential to inhibit the growth of S. aureus and E. coli bacteria.

Factors Influencing Mothers’ Knowledge about Seizures in Toddlers

Jumiyati Jumiyati — 2024-11-25

Febrile seizures are the most common neurological disorder in children, with 1 in 25 children having one febrile seizure. Febrile convulsions are seizures that occur when the body temperature rises (rectal temperature over 38°C) due to an extracranial process. Febrile seizures can result in behavioral disturbances as well as decreased intelligence and academic achievement. According to the World Health Organization (WHO), it is estimated that the number of children who experience febrile seizures in the world is more than 21.65 million and more than 216 thousand children die. Therefore, it is important that mothers know about seizures. This study aims to determine the factors that influence maternal knowledge about seizures based on age, parity and maternal education. This research is an analytic survey with a cross sectional approach. This study was conducted in the working area of Puskesmas Kolaka. The research sample was 82 respondents where the instrument used was a questionnaire. The results of the study there is an influence between age and maternal knowledge about seizures p=0.015, parity with maternal knowledge about seizures p=0.003, education with maternal knowledge about seizures p=0.025. Conclusion. there is an influence between age, parity and maternal education about seizures. Suggestions to improve mothers' knowledge about seizures by providing education and promotion about handling toddlers who experience febrile seizures.

Antibacterial Activity Test of Bougainvillea glabra Leaf Ethanol Extract on Staphylococcus aureus Bacteria

Mirna Legistari — 2024-11-25

Bougainvillea leaves contain various secondary metabolite compounds, such as flavonoids, tannins, and saponins. These compounds have the potential to be antibacterial to treat infectious diseases caused by the pathogenic bacteria Staphylococcus aureus. This study aims to determine the antibacterial activity of bougainvillea leaf ethanol extract against the growth of S. aureus bacteria. This study carried out antibacterial activity tests using the agar well-diffusion method. Data analysis used the One-way ANOVA statistical test, with the Shapiro-Wilk normality test and the Levene homogeneity test. The results of phytochemical tests showed that the ethanol extract of bougainvillea leaves contains flavonoids, tannins, and saponins. In antibacterial tests with concentrations of 25%, 50%, 75%, and 100%, the diameter of the inhibition zone obtained ranged from 20-27.3 cm. This inhibition zone is included in the strong to very strong category. In addition, statistical tests showed that each concentration of bougainvillea leaf ethanol extract affected the growth of S. aureus bacteria compared to negative controls. Based on the description above, bougainvillea leaf ethanol extract has the potential to inhibit the growth of S. aureus.